Evaluation of latent membrane protein 1 and microRNA-155 for the prognostic prediction of diffuse large B cell lymphoma.
Evaluation of latent membrane protein 1 and microRNA-155 for the prognostic prediction of diffuse large B cell lymphoma.
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DOI：
10.3892/ol.2018.8560
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发表时间：
2018-06
期刊：
影响因子：
2.9
通讯作者：
Chen B
中科院分区：
文献类型：
--
作者：
Wu X;Wang F;Li Y;Wang X;Liu P;Zhang H;Ge Z;Zhang X;Gao C;Chen B
先前已证明弥漫性大 B 细胞淋巴瘤 (DLBCL) 会导致具有各种侵袭性特征的淋巴瘤的死亡率。生物标志物潜伏膜蛋白 (LMP) 1 和 microRNA-(miR)-155 在 DLBCL 中的预后作用仍存在争议。本研究主要旨在评估LMP1和miR-155对DLBCL患者生存的影响，并与之前的研究相比评估临床特征以观察其对结果的影响。福尔马林固定、石蜡包埋样本于2010年5月至2011年12月期间从本中心采集。采用微阵列分析、免疫组化分析和逆转录定量聚合酶链反应评估LMP1和miR-155的表达。使用对数秩统计检验、Cox 比例风险模型和 Kaplan-Meier 方法评估生物标志物或临床特征与患者结果之间的关联。使用SPSS软件对数据进行统计分析。本研究共纳入 82 名患者。结果表明，LMP1和miR-155的高表达可能与较差的无进展生存率相关，而高国际预后指数评分和LMP1的高表达可能与较差的总生存率相关。这些结果表明，LMP1和miR-155可能是淋巴瘤预后预测的新颖且可靠的生物标志物，并且有可能在未来进行分析以评估患者预后。
Diffuse large B cell lymphoma (DLBCL) has previously been demonstrated to contribute to the mortality of lymphoma with various aggressive features. The prognostic role of the biomarkers latent membrane protein (LMP) 1 and microRNA-(miR)-155 in DLBCL remain controversial. The present study primarily aimed to assess the effect of LMP1 and miR-155 on the survival of DLBCL patients, and additionally evaluate the clinical features to observe their influence on outcomes, compared with previous studies. Formalin-fixed and paraffin-embedded samples were collected from our center between May 2010 and December 2011. Microarray analysis, immunohistochemical analysis and reverse transcription-quantitative polymerase chain reaction were used to evaluate the expression of LMP1 and miR-155. The association between biomarkers or clinical features and patient outcomes was assessed using the log-rank statistical test, Cox proportional hazard model and Kaplan-Meier method. SPSS software was used to statistically analyze the data. A total of 82 patients were included in the present study. The results demonstrated that high expression of LMP1 and miR-155 may be associated with a poor progression-free survival rate, while a high International Prognostic Index score and high expression of LMP1 may be associated with a poor overall survival rate. These results indicated that LMP1 and miR-155 may be novel and reliable biomarkers for the prognostic prediction of lymphoma, and will potentially be analyzed in the future to evaluate patient prognosis.
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