Medication use during pregnancy among women with congenital physical disabilities.
Medication use during pregnancy among women with congenital physical disabilities.
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DOI：
10.1002/bdr2.2048
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发表时间：
2022-08-15
影响因子：
2.1
通讯作者：
Werler, Martha M.
中科院分区：
文献类型：
--
作者：
Garcia, Michelle Huezo;Petersen, Julie M.;Parker, Samantha E.;Rubenstein, Eric;Werler, Martha M.
怀孕期间使用药物很常见，高达90%的孕妇至少服用一种药物。患有先天性身体残疾的妇女经常报告怀孕期间可能需要药物治疗的并发症，但研究有限。我们的目的是描述药物的使用在怀孕期间，包括：疼痛，精神和抗菌药物，在妇女和没有先天性身体残疾。我们使用了来自Slone出生缺陷研究（1976-2015）的数据，这是一项病例对照研究，收集了参与母亲的孕前健康状况和暴露信息。先天性身体残疾的女性（n = 132）包括脊柱裂、脑瘫、肌营养不良、肢体缺陷和其他骨骼/结缔组织疾病的女性，并按访谈年份和研究地点与无先天性身体残疾的女性（n = 528）相匹配。比较各组间每种药物的比例和比例差异。还计算了持续时间和多种药物使用变量的简单比例。先天性身体残疾的妇女更经常报告在怀孕期间使用疼痛（对乙酰氨基酚和阿片类药物），精神药物（抗抑郁药）和抗菌药物。先天性身体残疾的妇女使用止痛药和精神药物的时间更长，更频繁的持续时间，更频繁地报告说，在怀孕期间服用多种药物。与没有身体残疾的妇女相比，有先天性身体残疾的妇女报告在怀孕期间使用更多药物。模式可能是由于共同发生的条件或增加风险的妊娠并发症在这一人群中。需要进一步研究，以描述有关治疗残疾孕妇的临床决策的药物使用模式。
Medication use during pregnancy is common, with up to 90% of pregnant women taking at least one medication. Women with congenital physical disabilities often report co-occurring conditions during pregnancy that may warrant pharmaceutical treatment, however, research is limited. We aim to describe medication use during pregnancy including: pain, psychotropic, and antibacterial medication, among women with and without congenital physical disabilities. We used data from the Slone Birth Defects Study (1976–2015), a case–control study that collected information on pre-pregnancy health conditions and exposures among participating mothers. Women with congenital physical disabilities (n = 132) included women with spina bifida, cerebral palsy, muscular dystrophy, limb deficiencies, and other skeletal/connective tissue conditions and were matched by interview year and study site to women without congenital physical disabilities (n = 528). Proportions and difference in proportions for each medication were compared between groups. Simple proportions were also calculated for duration and multiple medication use variables. Women with congenital physical disabilities more frequently reported use of pain (acetaminophen and opioids), psychotropic (antidepressants), and antibacterial medications during pregnancy. Women with congenital physical disabilities used pain and psychotropic medications for longer, frequent durations, and more frequently reported haven taken multiple medications during pregnancy. Women with congenital physical disabilities report higher medication use during pregnancy compared to women without physical disabilities. Patterns may be attributable to co-occurring conditions or increased risk of pregnancy complications in this population. Further research is needed to describe the patterns of medication use for clinical decisions regarding treatment of pregnant women with disabilities.
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影响因子：
9.8
作者：
Mitchell AA;Gilboa SM;Werler MM;Kelley KE;Louik C;Hernández-Díaz S;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
DOI：
10.1016/j.apmr.2005.11.003
发表时间：
2006-03-01
影响因子：
4.3
作者：
Nosek, MA;Hughes, RB;Morgan, R
通讯作者：
Morgan, R
DOI：
10.1001/archpediatrics.2009.188
发表时间：
2009-11-01
影响因子：
--
作者：
Crider, Krista S.;Cleves, Mario A.;Hu, Dale J.
通讯作者：
Hu, Dale J.
影响因子：
3.6
作者：
Bellin, Melissa H.;Zabel, T. Andrew;Braun, Patricia
通讯作者：
Braun, Patricia
影响因子：
--
作者：
Banhidy, Ferenc;Acs, Nandor;Czeizel, Andrew E.
通讯作者：
Czeizel, Andrew E.