New frontiers in cell competition.

New frontiers in cell competition.
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DOI:
10.1002/dvdy.23783
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发表时间:
2012-05
影响因子:
2.5
通讯作者:
Johnston, Laura A.
Johnston, Laura A.
中科院分区:
生物学3区
文献类型:
--
作者:
de Beco, Simon;Ziosi, Marcello;Johnston, Laura A.

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细胞通讯是动物发育的核心,并指导细胞命运的规范,组织内和组织之间的细胞运动,以及不同身体部位的协调排列。在器官和组织的生长过程中,细胞间的通讯在决定细胞是否存活并为生物体做出贡献方面起着关键作用。在这篇综述中,我们讨论了最近对细胞竞争的见解,这是一种社会细胞现象,可以选择组织中最适合的细胞,因此可能有助于调节其生长和最终大小。在过去的几年里,细胞竞争领域的研究取得了巨大的发展,这得益于果蝇中日益复杂的遗传和分子技术,以及其与干细胞生物学和人类癌症的相关性。
Cellular communication is at the heart of animal development, and guides the specification of cell fates, the movement of cells within and between tissues, and the coordinated arrangement of different body parts. During organ and tissue growth, cell-cell communication plays a critical role in decisions that determine whether cells survive to contribute to the organism. In this review, we discuss recent insights into cell competition, a social cellular phenomenon that selects the fittest cells in a tissue, and as such potentially contributes to the regulation of its growth and final size. The field of cell competition has seen a huge explosion in its study in the last several years, facilitated by the increasingly sophisticated genetic and molecular technology available in Drosophila and driven by its relevance to stem cell biology and human cancer.
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