Maternal gestational diabetes in singleton pregnancies conceived by ART may be modified by periconceptional B vitamins.
Maternal gestational diabetes in singleton pregnancies conceived by ART may be modified by periconceptional B vitamins.
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DOI：
10.3389/fnut.2022.1069911
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发表时间：
2022
影响因子：
5
通讯作者：
Li, Guoju
中科院分区：
文献类型：
--
作者：
Li, Minyu;Chen, Yanping;Wang, Yongxiang;Wang, Hong;Ding, Xueteng;Li, Guoju
妊娠期糖尿病（GDM）的风险可能会受到通过辅助生殖技术（ART）怀孕的影响。但未考虑B族维生素（叶酸、维生素B6和维生素B12）剂量对GDM的影响。因此，我们假设，围受孕期B族维生素可以修改母亲GDM单胎妊娠ART受孕。这项研究是一项前瞻性队列研究，数据来自3,252名妇女单胎妊娠，并收到了75克口服葡萄糖耐量试验（OGTT）在24-28周的妊娠。我们分别在多变量逻辑回归和线性回归模型中加入了交互作用项来检验我们的假设。与自然妊娠妇女相比，接受ART的妇女与GDM的发病率显著相关。校正比值比（aOR）为1.59，95%置信区间（CI）为1.08-2.34。ART孕妇口服葡萄糖耐量试验（OGTT）1小时血糖水平和OGTT 2小时血糖水平也升高（P < 0.05）。膳食维生素B6（aOR = 1.60，95%CI：1.13-2.27）、膳食维生素B12（aOR = 1.88，95%CI：1.34-2.64）和膳食叶酸（aOR = 1.66，95%CI：1.19-2.32）与GDM风险之间的正相关性比较最高和最低四分位数（所有P趋势< 0.001）。补充叶酸不足（< 400 μg/d）、充足（400-800 μg/d）和过量（> 800 μg/d）的妊娠期糖尿病aOR分别为1.00、0.93和1.30（P趋势= 0.033）。由于仅补充叶酸说明了与ART的统计学显著相互作用（相互作用P < 0.05），因此进一步评估了ART与GDM和OGTT血糖水平之间的关联，通过补充叶酸分层。GDM的风险增加（aOR = 1.62，95%CI：1.39-3.39）和1 h血糖的回归系数（β）（β = 0.76，95% CI：0.39-1.13）和2小时血糖（β = 0.60，95%CI：0.29-0.92）仅在过量补充叶酸（> 800 μg/d）的ART组中显著。GDM的风险显著升高，特别是在摄入过量补充叶酸（> 800 μg/天）的ART的女性中。
The risk of maternal gestational diabetes mellitus (GDM) may be influenced by pregnancies conceived through assisted reproductive technology (ART). However, the influence of the dosage of B vitamins (folate, vitamin B6 and vitamin B12) on GDM weren’t considered. Thus, we hypothesized that periconceptional B vitamins could modify maternal GDM in singleton pregnancies conceived by ART. This study is a prospective cohort study using data from 3,252 women with singleton pregnancies and received a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation. We included an interaction term in the multivariable logistic and linear regression models, respectively, to test our hypothesis. Women who underwent ART were significantly associated with the incidence of GDM compared with spontaneous pregnancy women. The adjusted odds ratio (aOR) was 1.59, and the 95% confidence interval (CI) was 1.08–2.34. ART pregnancies also elevated OGTT (oral glucose tolerance test) 1-h blood glucose levels and OGTT 2-h blood glucose levels (P < 0.05). A positive association between dietary vitamin B6 (aOR = 1.60, 95% CI: 1.13–2.27), dietary vitamin B12 (aOR = 1.88, 95% CI: 1.34–2.64) and dietary folate (aOR = 1.66, 95% CI: 1.19–2.32) with GDM risk comparing the highest to the lowest quartile (all Ptrend < 0.001). The aORs of GDM for inadequate (< 400 μg/day), adequate (400–800 μg/day), and excessive (> 800 μg/day) supplemental folate intake were 1.00, 0.93, and 1.30, respectively (Ptrend = 0.033). Since only the supplemental folate illustrates a statistically significant interaction with ART (P for interaction < 0.05), the association between ART and GDM and OGTT blood glucose levels stratifying by supplemental folate were further evaluated. These increased risks of GDM (aOR = 1.62, 95% CI: 1.39–3.39) and the regression coefficients (β) of 1-h blood glucose (β = 0.76, 95% CI: 0.39–1.13) and 2-h blood glucose (β = 0.60, 95% CI: 0.29–0.92) in the multiple linear regression model were significant only in the ART group with excessive supplemental folate (> 800 μg/day). The risk of GDM is significantly elevated, particularly among those women who conceived ART with the intake of excessive supplemental folate (> 800 μg/day).
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DOI：
10.3390/ijerph182312280
发表时间：
2021-11-23
影响因子：
--
作者：
Cirillo M;Fucci R;Rubini S;Coccia ME;Fatini C
通讯作者：
Fatini C
影响因子：
16.2
作者：
Chen X;Zhang Y;Chen H;Jiang Y;Wang Y;Wang D;Li M;Dou Y;Sun X;Huang G;Yan W
通讯作者：
Yan W
DOI：
10.1016/j.clnu.2017.03.022
发表时间：
2018-06
期刊：
Clinical nutrition (Edinburgh, Scotland)
影响因子：
--
作者：
Lai JS;Pang WW;Cai S;Lee YS;Chan JKY;Shek LPC;Yap FKP;Tan KH;Godfrey KM;van Dam RM;Chong YS;Chong MFF
通讯作者：
Chong MFF
影响因子：
16.2
作者：
Black MH;Sacks DA;Xiang AH;Lawrence JM
通讯作者：
Lawrence JM
影响因子：
2.9
作者：
Nomura, Yoko;Lambertini, Luca;Chen, Jia
通讯作者：
Chen, Jia