5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.
5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.
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5-甲基四氢叶酸和维生素B12补充剂与接受辅助生殖技术的妇女的临床妊娠和活产相关。
DOI：
10.3390/ijerph182312280
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发表时间：
2021-11-23
影响因子：
--
通讯作者：
Fatini C
中科院分区：
文献类型：
--
作者：
Cirillo M;Fucci R;Rubini S;Coccia ME;Fatini C
应评估孕前时期的同型半胱氨酸途径，以突出微量营养素缺乏，并保证在辅助生殖之前补充最佳的多种维生素，作为孕前护理。我们进行了一项回顾性研究，旨在调查维生素B复合物的作用，（5-甲基四氢叶酸，维生素B12，维生素B6）补充剂的使用与仅使用叶酸补充剂的作用相比，与接受同源ART的不孕妇女的临床妊娠和活产有关。我们调查了269名因同源ART而转介到辅助生殖技术中心的高加索妇女。在这些妇女中，111例（A组）每日补充复合维生素B，158例（B组）仅补充叶酸。在A组中，中期II卵母细胞的平均数量和2PN受精率高于A组（分别为p = 0.04; p = 0.05）。与B组相比，A组中临床妊娠和活产的女性百分比更高（分别为p = 0.01; p = 0.02）。多变量校正后，维生素B复合物补充剂与临床妊娠（OR 2.03，p = 0.008）和活产（OR 1.83，p = 0.03）独立相关。与仅补充叶酸的妇女相比，补充5-MTHF和维生素B12的妇女临床妊娠和活产的机会更高。
The homocysteine pathway in the preconception period should be evaluated to highlight micronutrient deficiencies and warrants optimal multivitamin supplementation, before Assisted Reproduction, as preconception care. We conducted a retrospective study aimed at investigating the role of vitamin B complex (5-methyltetrahydrofolate, vitamin B12, vitamin B6) supplement use compared with the role of only folic acid supplement use, in relation to clinical pregnancy and live birth in infertile women undergoing homologous ART. We investigated 269 Caucasian women referred to the Centre for Assisted Reproductive Technology for homologous ART. In these women, 111 (Group A) were daily supplemented with vitamin B complex and 158 (Group B) with only folic acid. In group A the mean number of Metaphase II oocytes and the 2PN Fertilization Rate were higher in comparison to group A (p = 0.04; p = 0.05, respectively). A higher percentage of women in group A had a clinical pregnancy and live birth in comparison to group B (p = 0.01; p = 0.02, respectively). Vitamin B complex supplementation remained independently associated, after multivariable adjustment, with clinical pregnancy (OR 2.03, p = 0.008) and live birth (OR 1.83, p = 0.03). Women supplemented with 5-MTHF and vitamin B12, have a higher chance of clinical pregnancy and live birth in comparison to those supplemented with only folic acid.
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影响因子：
6.7
作者：
Vujkovic, Marijana;de Vries, Jeanne H.;Steegers-Theunissen, Regine P. M.
通讯作者：
Steegers-Theunissen, Regine P. M.
影响因子：
5.9
作者：
Rizzo G;Laganà AS;Rapisarda AM;La Ferrera GM;Buscema M;Rossetti P;Nigro A;Muscia V;Valenti G;Sapia F;Sarpietro G;Zigarelli M;Vitale SG
通讯作者：
Vitale SG
影响因子：
6.1
作者：
Berker, Buelent;Kaya, Cemil;Satiroglu, Hakan
通讯作者：
Satiroglu, Hakan
影响因子：
168.9
作者：
Haggarty, P;McCallum, H;Bhattachayra, S
通讯作者：
Bhattachayra, S
影响因子：
4.9
作者：
Unger, Thomas;Borghi, Claudio;Schutte, Aletta E.
通讯作者：
Schutte, Aletta E.