The influence of a manipulation of threat on experimentally-induced secondary hyperalgesia.
The influence of a manipulation of threat on experimentally-induced secondary hyperalgesia.
复制标题
威胁手法对实验诱导的继发性痛觉过敏的影响。
DOI：
10.7717/peerj.13512
复制
发表时间：
2022
期刊：
影响因子：
2.7
通讯作者：
Madden, Victoria J.
中科院分区：
文献类型：
--
作者：
Bedwell, Gillian J.;Louw, Caron;Parker, Romy;van den Broeke, Emanuel;Vlaeyen, Johan W.;Moseley, G. Lorimer;Madden, Victoria J.
关键词：
疼痛被认为受到发生疼痛的特定环境的威胁值的影响。然而，威胁对疼痛产生这种影响的机制尚不清楚。在这里，我们探索威胁如何影响实验诱导的继发性痛敏，这被认为是中枢敏化的一种表现。我们开展了一项实验研究，以调查操纵威胁对26名健康成人(16名女性，10名男性)实验诱导的继发性痛觉过敏的影响。我们用高频电刺激在两个前臂诱发继发性痛觉过敏。在诱导之前，我们使用了一种以前成功的方法来处理一个前臂(威胁部位)的组织损伤威胁。威胁操纵的效果是通过比较参与者在实验诱导的继发性痛觉过敏期间的焦虑、感觉到的威胁和疼痛来确定的，威胁部位和对照部位之间。我们假设，与对照部位相比，威胁部位将表现出更大的继发性痛敏(主要结果)和更大的表面积(次要结果)。尽管有一个全面的试验程序来测试威胁操纵，但我们的数据显示，在高频电刺激期间，站点对疼痛、焦虑或威胁评级没有主要影响。鉴于不同地点之间的威胁没有差异，主要和次要假设无法检验。我们讨论了为什么我们不能在我们的样本中复制这种已建立的威胁操纵的有效性的原因，包括：(1)威胁之间的竞争，(2)学习到的威胁值的泛化，(3)安全提示，(4)信任，以及对参与者安全的要求，(5)抽样偏差，(6)特定样本对威胁的习惯性，以及(7)(假)皮肤检查和报告的不可信。为了进一步研究威胁影响疼痛的机制，需要更好的策略来操纵威胁。
Pain is thought to be influenced by the threat value of the particular context in which it occurs. However, the mechanisms by which a threat achieves this influence on pain are unclear. Here, we explore how threat influences experimentally-induced secondary hyperalgesia, which is thought to be a manifestation of central sensitization. We developed an experimental study to investigate the effect of a manipulation of threat on experimentally-induced secondary hyperalgesia in 26 healthy human adults (16 identifying as female; 10 as male). We induced secondary hyperalgesia at both forearms using high-frequency electrical stimulation. Prior to the induction, we used a previously successful method to manipulate threat of tissue damage at one forearm (threat site). The effect of the threat manipulation was determined by comparing participant-rated anxiety, perceived threat, and pain during the experimental induction of secondary hyperalgesia, between the threat and control sites. We hypothesized that the threat site would show greater secondary hyperalgesia (primary outcome) and greater surface area (secondary outcome) of induced secondary hyperalgesia than the control site. Despite a thorough piloting procedure to test the threat manipulation, our data showed no main effect of site on pain, anxiety, or threat ratings during high-frequency electrical stimulation. In the light of no difference in threat between sites, the primary and secondary hypotheses cannot be tested. We discuss reasons why we were unable to replicate the efficacy of this established threat manipulation in our sample, including: (1) competition between threats, (2) generalization of learned threat value, (3) safety cues, (4) trust, and requirements for participant safety, (5) sampling bias, (6) sample-specific habituation to threat, and (7) implausibility of (sham) skin examination and report. Better strategies to manipulate threat are required for further research on the mechanisms by which threat influences pain.
登录
查看更多内容
影响因子：
5
作者：
Hinsberger M;Sommer J;Kaminer D;Holtzhausen L;Weierstall R;Seedat S;Madikane S;Elbert T
通讯作者：
Elbert T
影响因子：
1.6
作者：
Caneiro, J. P.;O'Sullivan, Peter;Lipp, Ottmar V.
通讯作者：
Lipp, Ottmar V.
影响因子：
1
作者：
Hartley, Michael T.
通讯作者：
Hartley, Michael T.
影响因子：
2.8
作者：
Frenkel, Louise;Swartz, Leslie;Bantjes, Jason
通讯作者：
Bantjes, Jason
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W