Present and Future Therapy of Cryptococcus Infections.

Present and Future Therapy of Cryptococcus Infections.
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加密环球感染的当前和未来疗法。

DOI:
10.3390/jof4030079
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发表时间:
2018-07-03
期刊:
Journal of fungi (Basel, Switzerland)
影响因子:
--
通讯作者:
Perfect JR
Perfect JR
中科院分区:
其他
文献类型:
--
作者:
Mourad A;Perfect JR

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隐球菌感染给免疫功能低下的人群带来了不可接受的高发病率和死亡率。这一人群包括艾滋病毒感染者和接受器官移植的人,以及表面上具有免疫能力的患者(非艾滋病毒,非移植)。这些群体很难用目前的治疗选择和策略来管理,特别是在资源有限的情况下。旨在为资源有限的国家提供最佳治疗策略以降低成本和不良反应的新试验集中在缩短治疗时间和使用更容易获得的抗真菌药物,如氟康唑。此外,抗真菌耐药性的出现对成功治疗提出了另一个挑战,可能需要开发新的药物来改善管理。这篇综述将讨论管理的原则,当前和未来的抗真菌药物,以及新兴技术和未来的护理方向,这种致命的感染。
Cryptococcal infections burden the immunocompromised population with unacceptably high morbidity and mortality. This population includes HIV-infected individuals and those undergoing organ transplants, as well as seemingly immunocompetent patients (non-HIV, non-transplant). These groups are difficult to manage with the current therapeutic options and strategies, particularly in resource-limited settings. New trials aimed at providing the best treatment strategies for resource-limited countries that will reduce costs and adverse reactions have focused on decreasing the length of therapy and using more readily accessible antifungal agents such as fluconazole. Furthermore, the emergence of antifungal resistance poses another challenge for successful treatment and may require the development of new agents for improved management. This review will discuss the principles of management, current and future antifungal agents, as well as emerging techniques and future directions of care for this deadly infection.
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