TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway.
TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway.
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通过胰岛素/AKT信号通路参与脂肪组织中葡萄糖代谢参与葡萄糖代谢。
DOI：
10.1155/2020/6942307
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发表时间：
2020
影响因子：
2.8
通讯作者：
Fukuchi KI
中科院分区：
文献类型：
--
作者：
Yang J;Fukuchi KI
Obesity significantly increases the risk of developing type 2 diabetes mellitus and other metabolic diseases. Obesity is associated with chronic low-grade inflammation in white adipose tissues, which is thought to play an essential role in developing insulin resistance. Many lines of evidence indicate that toll-like receptors (TLRs) and their downstream signaling pathways are involved in development of chronic low-grade inflammation and insulin resistance, which are associated with obesity. Mice lacking molecules positively involved in the TLR signaling pathways are generally protected from high-fat diet-induced inflammation and insulin resistance. In this study, we have determined the effects of genetic deficiency of toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-β (TRIF) on food intake, bodyweight, glucose metabolism, adipose tissue macrophage polarization, and insulin signaling in normal chow diet-fed mice to investigate the role of the TRIF-dependent TLR signaling in adipose tissue metabolism and inflammation. TRIF deficiency (TRIF−/−) increased food intake and bodyweight. The significant increase in bodyweight in TRIF−/− mice was discernible as early as 24 weeks of age and sustained thereafter. TRIF−/− mice showed impaired glucose tolerance in glucose tolerance tests, but their insulin tolerance tests were similar to those in TRIF+/+ mice. Although no difference was found in the epididymal adipose mass between the two groups, the percentage of CD206+ M2 macrophages in epididymal adipose tissue decreased in TRIF−/− mice compared with those in TRIF+/+ mice. Furthermore, activation of epididymal adipose AKT in response to insulin stimulation was remarkably diminished in TRIF−/− mice compared with TRIF+/+ mice. Our results indicate that the TRIF-dependent TLR signaling contributes to maintaining insulin/AKT signaling and M2 macrophages in epididymal adipose tissue under a normal chow diet and provide new evidence that TLR4-targeted therapies for type 2 diabetes require caution.
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影响因子：
3.5
作者：
Gomes Torres, Ana Claudia M. B.;Leite, Neiva;Furtado-Alle, Lupe
通讯作者：
Furtado-Alle, Lupe
影响因子：
6.9
作者：
Mahmassani, Ziad S.;Reidy, Paul T.;Drummond, Micah J.
通讯作者：
Drummond, Micah J.
影响因子：
--
作者：
Liu F;Lu W;Qian Q;Qi W;Hu J;Feng B
通讯作者：
Feng B
DOI：
10.1016/j.bbadis.2013.05.017
发表时间：
2014-03
影响因子：
6.2
作者：
Lee, Byung-Cheol;Lee, Jongsoon
通讯作者：
Lee, Jongsoon
影响因子：
2
作者：
Ermiş Karaali Z;Candan G;Aktuğlu MB;Velet M;Ergen A
通讯作者：
Ergen A