Evaluation of cerebral infarction with iodine 123-iomazenil SPECT.
Evaluation of cerebral infarction with iodine 123-iomazenil SPECT.
复制标题
碘 123-碘马西尼 SPECT 评估脑梗塞。
作者：
J. Hatazawa;T. Satoh;E. Shimosegawa;T. Okudera;A. Inugami;T. Ogawa;H. Fujita;K. Noguchi;I. Kanno;S. Miura
未标记
本研究评价了与CT低密度病变和血流异常相关的[123]碘马替尼SPECT脑内中枢苯二氮卓类（BZD）受体结合的缺血性损伤。
方法
本文报告9例大脑中动脉供血区梗塞。分析注射后180分钟获得的Iomazenil图像的BZD受体结合。采用病灶与对侧镜像区的比值（L/C比值）分析皮质梗死区（CT显示为低密度区）、梗死周围区（CT显示为正常密度区）、半球内远隔区和小脑。慢性期的CT和两项研究之间最小时间差期间获得的灌注图像用于比较分析。
结果
在梗死区、梗死周围区、远隔区和小脑中，碘马唑尼摄取的平均L/C比值分别为0.53 ± 0.08、0.79 ± 0.07、0.98 ± 0.03和1.00 ± 0.04。梗死区和梗死周边区面积较统一区明显缩小。相应的血流平均L/C比分别为0.52 +/- 0.08、0.73 +/- 0.07、0.83 +/- 0.09和0.80 +/- 0.07。在所有地区，与统一相比，比率都大幅下降。远隔区和小脑的L/C比值与碘马唑尼比较有显著性差异。
结论
碘-123-iomazenil SPECT显像可能提供新的信息缺血性损伤的大脑，特别是神经元。
UNLABELLED
This study evaluates ischemic damage to central benzodiazepine (BZD) receptor binding in the brain with [123]iomazenil SPECT in relation to CT hypodense lesions and blood flow abnormalities.
METHODS
Nine patients with middle cerebral artery territory infarction were studied. Iomazenil images obtained 180 min postinjection were analyzed for BZD receptor binding. The cortical infraction, visualized as CT hypodense area on CT, the peri-infarct area, visualized as normodensity surrounding the infarction on CT, the intrahemispheric remote area and the cerebellum were analyzed by taking the ratio of the lesion to contralateral mirror region (L/C ratio). CT during the chronic stage and perfusion images obtained during the smallest time difference between the two studies were used for comparative analysis.
RESULTS
The mean L/C ratio of iomazenil uptake was 0.53 +/_ 0.08, 0.79 +/- 0.07, 0.98 +/- 0.03 and 1.00 +/- 0.04 in the infarct, peri-infarct and remote areas and the cerebellum, respectively. The infarct and peri-infarct areas showed significant decrease compared with unity. The corresponding mean L/C ratio for blood flow was 0.52 +/- 0.08, 0.73 +/- 0.07, 0.83 +/- 0.09, and 0.80 +/- 0.07, respectively. In all areas, the ratios were significantly decreased compared with unity. There was significant difference between the L/C ratio for blood flow and iomazenil in the remote area and the cerebellum.
CONCLUSION
Iodine-123-iomazenil SPECT imaging may provide new information on ischemic damage to the brain, particularly neurons.
DOI：
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发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
DOI：
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发表时间：
2006
期刊：
--
影响因子：
--
作者：
M. Mintun;M. Raichle;W. Martin
通讯作者：
M. Mintun;M. Raichle;W. Martin
使用 [123I]Ro 16-0154 对非人灵长类动物脑中苯二氮卓受体进行 SPECT 成像。
影响因子：
5
作者：
Innis,R;Zoghbi,S;Johnson,E;Woods,S;al-Tikriti,M;Baldwin,R;Seibyl,J;Malison,R;Zubal,G;Charney,D
通讯作者：
Charney,D