Dissociable attentional and affective circuits in medication-naïve children with attention-deficit/hyperactivity disorder.
Dissociable attentional and affective circuits in medication-naïve children with attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.pscychresns.2013.01.004
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发表时间：
2013-07-30
影响因子：
11.3
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Posner J;Rauh V;Gruber A;Gat I;Wang Z;Peterson BS
当前注意力缺陷/多动障碍（ADHD）的神经认知模型表明，涉及注意力和情感处理的神经回路对该疾病的现象学做出了独立的贡献。然而，在未接受药物治疗的多动症儿童中，注意力和情感回路及其行为相关性的明显分离尚未得到证实。通过对一组患有 ADHD（N=22）和不患有 ADHD（N=20）的未接受药物治疗的儿童进行静息态功能连接 MRI (rs-fcMRI)，我们证明患有 ADHD 的儿童在两个神经回路中的连接性降低：一个是潜在的执行注意力 (EA)，另一个是情绪调节 (ER)。我们还证明了这两个神经回路及其行为相关性之间的双重分离，即 EA 回路中的连通性降低与执行注意力缺陷相关，但与情绪不稳定性无关，而另一方面，ER 回路中的连通性降低与情绪不稳定性相关，但与执行注意力缺陷无关。这些发现为未来的研究提供了潜在的途径，例如检查对这两种神经回路的治疗效果，以及一种回路与另一种回路的干扰的潜在预后和发育意义。
Current neurocognitive models of attention-deficit/hyperactivity disorder (ADHD) suggest that neural circuits involving both attentional and affective processing make independent contributions to the phenomenology of the disorder. However, a clear dissociation of attentional and affective circuits and their behavioral correlates has yet to be shown in medication-naïve children with ADHD. Using resting-state functional connectivity MRI (rs-fcMRI) in a cohort of medication naïve children with (N=22) and without (N=20) ADHD, we demonstrate that children with ADHD have reduced connectivity in two neural circuits: one underlying executive attention (EA) and the other emotional regulation (ER). We also demonstrate a double dissociation between these two neural circuits and their behavioral correlates such that reduced connectivity in the EA circuit correlates with executive attention deficits but not with emotional lability, while on the other hand, reduced connectivity in the ER circuit correlates with emotional lability but not with executive attention deficits. These findings suggest potential avenues for future research such as examining treatment effects on these two neural circuits as well as the potential prognostic and developmental significance of disturbances in one circuit vs the other.
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影响因子：
3
作者：
Bitsakou, P;Antrop, I;Sonuga-Barke, EJS
通讯作者：
Sonuga-Barke, EJS
影响因子：
10.6
作者：
Nigg, JT;Willcutt, EG;Sonuga-Barke, EJS
通讯作者：
Sonuga-Barke, EJS
DOI：
10.1207/s15374424jccp2003_3
发表时间：
1991-09-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
DUPAUL, GJ
通讯作者：
DUPAUL, GJ
影响因子：
5.3
作者：
Biederman, Joseph;Petty, Carter R.;Faraone, Stephen V.
通讯作者：
Faraone, Stephen V.
影响因子：
1.9
作者：
Aylward, EH;Reiss, AL;Denckla, MB
通讯作者：
Denckla, MB