In tendons, differing physiological requirements lead to functionally distinct nanostructures.
In tendons, differing physiological requirements lead to functionally distinct nanostructures.
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DOI：
10.1038/s41598-018-22741-8
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发表时间：
2018-03-13
影响因子：
4.6
通讯作者：
Veres SP
中科院分区：
文献类型：
--
作者：
Quigley AS;Bancelin S;Deska-Gauthier D;Légaré F;Kreplak L;Veres SP
动物的胶原蛋白组织是等级结构：即使是肌腱，最简单的胶原组织，也有七到八个等级。调整组织结构以匹配生理功能可以发生在许多不同的水平。我们想知道，实现功能的组织结构控制是否延伸到单个索状胶原纤维的纳米级。以青年牛前肢肌腱为材料，对具有定位功能的肌腱和具有储能功能的肌腱提取的单一胶原纤维进行了应力应变实验。两种肌腱类型的胶原纤维在分子间交联方面存在已知的差异，在对伸长的反应方面也显示出许多不同。与位置肌腱不同，来自储能肌腱的纤维在分子堆积和构象上都表现出高应变硬化和抗破坏能力，这有助于解释这些高应力组织如何承受数百万次载荷循环，几乎没有修复重塑。承载组织的功能差异伴随着纳米级胶原原纤维结构的重要差异。
The collagen-based tissues of animals are hierarchical structures: even tendon, the simplest collagenous tissue, has seven to eight levels of hierarchy. Tailoring tissue structure to match physiological function can occur at many different levels. We wanted to know if the control of tissue architecture to achieve function extends down to the nanoscale level of the individual, cable-like collagen fibrils. Using tendons from young adult bovine forelimbs, we performed stress-strain experiments on single collagen fibrils extracted from tendons with positional function, and tendons with energy storing function. Collagen fibrils from the two tendon types, which have known differences in intermolecular crosslinking, showed numerous differences in their responses to elongation. Unlike those from positional tendons, fibrils from energy storing tendons showed high strain stiffening and resistance to disruption in both molecular packing and conformation, helping to explain how these high stress tissues withstand millions of loading cycles with little reparative remodeling. Functional differences in load-bearing tissues are accompanied by important differences in nanoscale collagen fibril structure.
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影响因子：
2.7
作者：
Buehler, Markus J.
通讯作者：
Buehler, Markus J.
影响因子：
9.7
作者：
Herod, Tyler W.;Chambers, Neil C.;Veres, Samuel P.
通讯作者：
Veres, Samuel P.
DOI：
10.1111/j.1365-2613.2007.00552.x
发表时间：
2007-08-07
影响因子：
3
作者：
Birch, Helen L.
通讯作者：
Birch, Helen L.
影响因子：
3.4
作者：
Kreplak, Laurent;Herrmann, Harald;Aebi, Ueli
通讯作者：
Aebi, Ueli
影响因子：
56.9
作者：
Liu, W.;Jawerth, L. M.;Guthold, M.
通讯作者：
Guthold, M.