Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone.
Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone.
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DOI：
10.1186/1746-6148-4-32
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发表时间：
2008-08-13
影响因子：
2.6
通讯作者：
Kiupel M
中科院分区：
文献类型：
--
作者：
Webster JD;Yuzbasiyan-Gurkan V;Thamm DH;Hamilton E;Kiupel M
犬皮肤肥大细胞瘤（MCT）是一种常见的肿瘤性疾病，其生物学行为多变。手术仍然是犬MCT的主要治疗方法;然而，放射治疗（RT）和化疗通常用于治疗侵袭性MCT。本研究的目的是评价术后接受长春碱和泼尼松+/- RT治疗的犬的组织学分级、c-KIT突变、KIT染色模式和增殖标志物Ki 67和AgNOR的预后效用，并比较术后接受化疗+/- RT治疗的犬与单纯手术治疗的病理匹配组的结局。评估了预后标志物与生存率之间的关系。将术前预后指数相似的犬术后化疗后的无病间期（DFI）和总生存时间（OS）与仅手术治疗的犬进行比较。组织学3级MCT、具有c-KIT突变的MCT、具有细胞质KIT增加的MCT以及具有Ki 67和AgNOR值增加的MCT与DFI和OS降低相关。当接受化疗与单独手术治疗时，具有组织学3级MCT的犬的DFI和OS显著增加。尽管由于样本量小而无统计学显著性，但与仅手术治疗相比，接受化疗治疗时，具有c-KIT突变的MCT的DFI和OS增加。本研究证实了犬MCT的组织学分级、c-KIT突变、KIT染色模式和增殖分析的预后价值。此外，本研究的结果进一步确定了术后长春碱和泼尼松治疗组织学3级MCT的获益。
Canine cutaneous mast cell tumor (MCT) is a common neoplastic disease associated with a variable biologic behavior. Surgery remains the primary treatment for canine MCT; however, radiation therapy (RT) and chemotherapy are commonly used to treat aggressive MCT. The goals of this study were to evaluate the prognostic utility of histologic grade, c-KIT mutations, KIT staining patterns, and the proliferation markers Ki67 and AgNORs in dogs postoperatively treated with vinblastine and prednisone +/- RT, and to compare the outcome of dogs treated with post-operative chemotherapy +/- RT to that of a prognostically matched group treated with surgery alone. Associations between prognostic markers and survival were evaluated. Disease-free intervals (DFI) and overall survival times (OS) of dogs with similar pretreatment prognostic indices postoperatively treated with chemotherapy were compared to dogs treated with surgery alone. Histologic grade 3 MCTs, MCTs with c-KIT mutations, MCTs with increased cytoplasmic KIT, and MCTs with increased Ki67 and AgNOR values were associated with decreased DFI and OS. Dogs with histologic grade 3 MCT had significantly increased DFI and OS when treated with chemotherapy vs. surgery alone. Although not statistically significant due to small sample sizes, MCTs with c-KIT mutations had increased DFI and OS when treated with chemotherapy vs. surgery alone. This study confirms the prognostic value of histologic grade, c-KIT mutations, KIT staining patterns, and proliferation analyses for canine MCT. Additionally, the results of this study further define the benefit of postoperative vinblastine and prednisone for histologic grade 3 MCTs.
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影响因子：
1.5
作者：
Northrup, NC;Harmon, BG;Howerth, EW
通讯作者：
Howerth, EW
影响因子：
4.8
作者：
Webster, Joshua D.;Yuzbasiyan-Gurkan, Vilma;Kiupel, Matti
通讯作者：
Kiupel, Matti
影响因子：
2.4
作者：
PATNAIK, AK;EHLER, WJ;MACEWEN, EG
通讯作者：
MACEWEN, EG
影响因子：
1.3
作者：
Weisse, C;Shofer, FS;Sorenmo, K
通讯作者：
Sorenmo, K
DOI：
10.2460/javma.2001.218.1120
发表时间：
2001-04-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Séguin, B;Leibman, NF;Withrow, SJ
通讯作者：
Withrow, SJ