Maternal birthweight is associated with subsequent risk of vitamin D deficiency in early pregnancy.
Maternal birthweight is associated with subsequent risk of vitamin D deficiency in early pregnancy.
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DOI：
10.1111/ppe.12069
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发表时间：
2013-09
影响因子：
2.8
通讯作者：
Enquobahrie DA
中科院分区：
文献类型：
--
作者：
Huang JY;Qiu C;Miller RS;Siscovick DS;Williams MA;Enquobahrie DA
孕妇低出生体重和孕期维生素D缺乏与类似的不良妊娠结局谱相关，包括先兆子痫和妊娠期糖尿病。然而，母亲出生体重和随后的维生素D浓度之间的关系在很大程度上是未知的。我们在一个妊娠队列（n=658）中评估了自我报告的母亲出生体重是否与早孕维生素D缺乏（≥20 ng/mL）风险相关。维生素D（25[OH]D）使用液相色谱-串联质谱法测定。校正母体特征和抽血月份后，母体出生体重增加100 g与早孕25[OH]D缺乏风险降低5.7%相关（OR = 0.94，[95%CI：0.90，0.99]）。低出生体重（<2，500 g）妇女发生早孕25[OH]D缺乏的可能性是正常出生体重妇女的3.7倍（OR = 3.69，[95%CI：1.63，8.34]）。这些关系不受孕前超重状态（BMI ≥25 kg/m2）或成年体重轨迹（从18岁到孕前BMI变化≥2 kg/m2）的影响。对决定出生体重和维生素D稳态的共同发育机制的进一步研究可能有助于确定不良妊娠和出生结果的目标和相关预防措施。
Maternal low birthweight and vitamin D deficiency in pregnancy are associated with a similar spectrum of adverse pregnancy outcomes including preeclampsia and gestational diabetes. However, the relationship between maternal birthweight and subsequent vitamin D concentrations in early pregnancy is largely unknown. We assessed whether self-reported maternal birthweight was associated with risk of early pregnancy vitamin D deficiency (≥20 ng/mL) among a pregnancy cohort (n=658). Vitamin D (25[OH]D) was measured using liquid chromatography-tandem mass spectroscopy. Adjusting for maternal characteristics and month of blood draw, a 100-gram higher maternal birthweight was associated with a 5.7% decreased risk of early pregnancy 25[OH]D deficiency (OR = 0.94, [95% CI: 0.90, 0.99]). Low birthweight (<2,500 g) women were 3.7 times as likely to have early pregnancy 25[OH]D deficiency compared to normal birthweight women (OR = 3.69, [95% CI: 1.63, 8.34]). These relationships were not modified by either pre-pregnancy overweight status (BMI ≥25 kg/m2) or adulthood weight trajectory (BMI change ≥2 kg/m2 from age 18 to pre-pregnancy). Further research on shared developmental mechanisms that determine birthweight and vitamin D homeostasis may help identify targets and related preventative measures for adverse pregnancy and birth outcomes.
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