Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline.
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline.
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DOI：
10.1038/s41398-018-0128-4
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发表时间：
2018-04-18
影响因子：
6.8
通讯作者：
Benkelfat C
中科院分区：
文献类型：
--
作者：
Lissemore JI;Sookman D;Gravel P;Berney A;Barsoum A;Diksic M;Nordahl TE;Pinard G;Sibon I;Cottraux J;Leyton M;Benkelfat C
认知行为疗法(CBT)和选择性5-羟色胺再摄取抑制剂(SSRI)对某些强迫症(OCD)患者都是有效的治疗方法，但与这些治疗方式相关的神经化学变化知之甚少。在这里，我们使用正电子发射断层扫描和α-[11C]甲基-L-色氨酸示踪剂检测了强迫症患者接受CBT或SSRI治疗后脑局部5-羟色胺合成能力的变化。16名未服用药物的强迫症患者被随机分配到CBT或舍曲林治疗12周。观察治疗前后α-[11C]甲基-L-色氨酸脑电捕获常数K*(ml/g/min)的变化与症状改善的关系。应答者/部分应答者在相对区域示踪剂摄取方面没有明显变化；相反，在应答者/部分应答者中，12周的治疗导致全脑5-羟色胺合成能力的增加。无论治疗方式如何，基线的中缝核团5-羟色胺合成能力与临床改善呈正相关。这些观察表明，对于一些患者来说，强迫症症状的成功治疗可能与更高的5-羟色胺能张力有关。
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these treatment modalities. Here, we used positron emission tomography and the α-[11C]methyl-l-tryptophan tracer to examine the changes in brain regional serotonin synthesis capacity in OCD patients following treatment with CBT or SSRI treatment. Sixteen medication-free OCD patients were randomly assigned to 12 weeks of either CBT or sertraline treatment. Pre-to-post treatment changes in the α-[11C]methyl-l-tryptophan brain trapping constant, K* (ml/g/min), were assessed as a function of symptom response, and correlations with symptom improvement were examined. Responders/partial responders to treatment did not show significant changes in relative regional tracer uptake; rather, in responders/partial responders, 12 weeks of treatment led to serotonin synthesis capacity increases that were brain-wide. Irrespective of treatment modality, baseline serotonin synthesis capacity in the raphe nuclei correlated positively with clinical improvement. These observations suggest that, for some patients, successful remediation of OCD symptoms might be associated with greater serotonergic tone.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
--
作者：
Berney, Alexandre;Leyton, Marco;Benkelfat, Chawki
通讯作者：
Benkelfat, Chawki
影响因子：
2.3
作者：
Apostolova, Ivayla;Block, Suzette;Obrocki, Jost
通讯作者：
Obrocki, Jost
影响因子：
7.6
作者：
ELMANSARI, M;BOUCHARD, C;BLIER, P
通讯作者：
BLIER, P
影响因子：
4.2
作者：
Berney, Alexandre;Nishikawa, Masami;Diksic, Mirko
通讯作者：
Diksic, Mirko