Deferred feeding and body weight responses to short-term interruption of fuel acquisition: impact of estradiol.
Deferred feeding and body weight responses to short-term interruption of fuel acquisition: impact of estradiol.
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DOI：
10.1055/s-0034-1387792
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Briski KP
中科院分区：
文献类型：
--
作者：
Ibrahim BA;Briski KP
在现代生活中，有计划或计划外的短期禁食是不可避免的，但与食欲控制和肥胖呈负相关。本研究探讨了雌二醇在短时间停饲后饲养和体重（bw）反应中的作用。在急性1-6小时重新喂食期间，FD（12小时无食物）-苯甲酸雌二醇（EB）植入的去卵巢大鼠比FD植入油(O)的大鼠进食更少，体重增加更少。全饲(FF)-和FD-EB在24小时内摄入等量的食物，但后者的体重增加更大；FD-O组24小时摄食量和体重增加均超过FD-EB组。尾侧第四脑室给予AMPK激活剂AICAR增加了FD-EB和-O中背迷走神经复合物AMPK的活性，但引起了下丘脑代谢神经肽递质表达的不同调节，同时分别增强或减少了这些动物的急性再喂养，逆转了FD-O的体重增加。经药物处理的FD-EB和FD-O在6-24小时内分别表现出摄食和增重的增加。与FF-EB相比，AICAR增加了FD-EB的24小时摄取量，但与FD-EB相比，AICAR处理的FD-O的累积摄取量和体重增加更大。结果表明，雌二醇限制了短期停食后的急性再摄食，但当能量消耗与停食同时发生时，雌二醇增加了急性再摄食。这种复合代谢应激在后来恢复由昼夜节律引起的喂养时产生类固醇依赖效应，例如，在雌二醇存在与不存在的情况下，消耗增加与体重增加。这些研究提供了新的证据，雌激素减轻急性和急性后的不良影响，破坏燃料获取能量平衡。
Short-term abstinence from food intake, planned or unplanned, is unavoidable in modern life, but negatively correlated with appetite control and obesity. This study investigated the role of estradiol in feeding and body weight (bw) reactions to short-span cessation of feeding. During acute 1-6 hr re-feeding, FD (12 hr food-deprived)-estradiol benzoate (EB)-implanted ovariectomized rats ate less food and gained less weight than FD animals implanted with oil (O). Full fed (FF)- and FD-EB consumed equal amounts of food over 24 hr, but weight gain was greater in the latter; 24 hr food intake and bw gain in FD-O exceeded FD-EB. Caudal fourth ventricular administration of the AMPK activator AICAR increased dorsal vagal complex AMPK activity in FD-EB and -O, but elicited dissimilar adjustments in hypothalamic metabolic neuropeptide transmitter expression, while respectively enhancing or reducing acute re-feeding in these animals and reversing FD-O weight gain. Drug-treated FD-EB and FD-O exhibited respective feeding and weight gain increases between 6-24 hrs. AICAR enhanced 24 hr consumption in FD-EB versus FF-EB, but cumulative intake and bw gain were greater in AICAR-treated FD-O versus FD-EB. Results show that estradiol limits acute re-feeding after short-term feeding suspension, but augments acute re-feeding when energy depletion coincides with suspended feeding. This compound metabolic stress exerts steroid-dependent effects during later resumption of circadian-induced feeding, e.g. increased consumption versus weight gain in the presence versus absence of estradiol. These studies provide novel evidence that estrogen mitigates acute and post-acute adverse effects of disrupted fuel acquisition on energy balance.
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影响因子：
3.2
作者：
Briski, K. P.;Nedungadi, T. P.
通讯作者：
Nedungadi, T. P.
影响因子：
4.1
作者：
Briski, KP;Marshall, ES;Sylvester, PW
通讯作者：
Sylvester, PW
影响因子：
4.8
作者：
Temel, S;Lin, W;Jennes, L
通讯作者：
Jennes, L
影响因子：
2.9
作者：
Butera, Peter C.
通讯作者：
Butera, Peter C.
影响因子：
4.2
作者：
Ibrahim, Baher A.;Tamrakar, Pratistha;Briski, Karen P.
通讯作者：
Briski, Karen P.