Estradiol and the control of food intake.
Estradiol and the control of food intake.
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DOI：
10.1016/j.physbeh.2009.06.010
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发表时间：
2010-02-09
影响因子：
2.9
通讯作者：
Butera, Peter C.
中科院分区：
文献类型：
--
作者：
Butera, Peter C.
性腺类固醇是影响哺乳动物摄食量和体重的众多因素之一。激素对这些过程的影响在雌性大鼠中尤其显著，雌性大鼠在卵巢切除术后表现出食物摄入量和体重的大幅增加。雌二醇在控制人类食物摄入和能量平衡中的关键作用由绝经后肥胖症的发生率大大增加的事实证明。雌二醇对调节饮食的神经系统的作用也可能部分解释了食物摄入和饮食失调的性别差异，这些差异在年轻女性中更常见。本文简要回顾了卵巢周期中摄食的变化、雌二醇停药和替代对摄食量和体重的影响以及雌二醇影响摄食行为的神经生物学机制。从这项研究中出现的激素对食物摄入的作用模型认为雌二醇是对进食和膳食大小的间接控制，通过调节代表直接控制进食的饱腹和食欲肽的中枢处理来改变进食行为。文中还讨论了该模型的一些不足之处和今后的研究方向。
Gonadal steroids are among the many factors that influence food intake and body weight in mammals. Hormonal effects on these processes are particularly striking in female rats, which show large increases in food intake and body weight after ovariectomy. A key role of estradiol in the control of food intake and energy balance in humans is evidenced by the fact that the incidence of obesity increases greatly after menopause. The actions of estradiol on neural systems that regulate eating may also account in part for sex differences in food intake and eating disorders, which occur much more frequently in young women. This paper presents a minireview of research examining the changes in feeding that occur during the ovarian cycle, the effects of estradiol withdrawal and replacement on food intake and body weight, and the neurobiological mechanisms by which estradiol influences feeding behavior. A model of hormone action on food intake that emerges from this research views estradiol as an indirect control of eating and meal size, producing changes in feeding behavior by modulating the central processing of both satiating and orexigenic peptides that represent direct controls of eating. Some of the shortcomings of the model and directions for future research are discussed.
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影响因子：
3
作者：
Eckel, LA;Geary, N
通讯作者：
Geary, N
DOI：
10.1006/bbrc.2002.6737
发表时间：
2002-04-12
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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