Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.
Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.
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早产儿的临床神经影像学：诊断和预后。
DOI：
10.1016/j.nicl.2017.08.015
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Jacokes Z
中科院分区：
文献类型：
--
作者：
Hinojosa-Rodríguez M;Harmony T;Carrillo-Prado C;Van Horn JD;Irimia A;Torgerson C;Jacokes Z
过去二十年来出现的围产期护理进步有助于降低极早产儿和极早产儿的死亡率和严重神经系统发病率（例如，囊性脑室周围白质软化[c-PVL]和脑胶质瘤出血-脑室内出血[GMH-IVH 3-4/4级];胎龄22至< 32周，GA）。然而，与轻度至中度白色和灰质损伤相关的运动和/或认知障碍经常存在于该人群中（例如，非囊性脑室周围白质软化[非囊性PVL]、神经元-轴突损伤和GMH-IVH 1-2/4级）。使用磁共振成像（MRI）进行的脑部研究报告称，50%至80%的极早产儿和极早产儿具有弥漫性白色异常（WMA），其仅对应于最低严重程度。然而，轻度至中度弥漫性WMA也与运动和认知活动的显著影响有关。由于新生儿存活率的增加和弥漫性WMA的固有特征，越来越需要使用对显微镜和/或弥漫性病变敏感的非侵入性神经成像技术来研究早产儿的大脑。这一新出现的需求促使科学界试图弥合不同方法和途径的概念或想法之间的差距;例如，神经病理学、神经成像和临床发现。这是显而易见的，结合密集的临床前和临床病理学研究沿着新生儿神经学和定量神经影像学研究。在下面的综述中，我们探讨了与早产儿和围产期脑损伤婴儿最常见的神经病理学模式与最近的神经影像学发现相关的文献。具体来说，我们集中讨论使用神经影像学来辅助诊断，测量形态学脑损伤，并跟踪长期的神经发育结果。MRI是早产儿诊断和长期预后的有力工具。脑损伤的神经病理学特征是MRI诊断的基础。对于一个准确的MRI诊断是必不可少的考虑形态演变。定量MRI提供了对长期运动预后非常有帮助的信息。
Perinatal care advances emerging over the past twenty years have helped to diminish the mortality and severe neurological morbidity of extremely and very preterm neonates (e.g., cystic Periventricular Leukomalacia [c-PVL] and Germinal Matrix Hemorrhage – Intraventricular Hemorrhage [GMH-IVH grade 3–4/4]; 22 to < 32 weeks of gestational age, GA). However, motor and/or cognitive disabilities associated with mild-to-moderate white and gray matter injury are frequently present in this population (e.g., non-cystic Periventricular Leukomalacia [non-cystic PVL], neuronal–axonal injury and GMH-IVH grade 1–2/4). Brain research studies using magnetic resonance imaging (MRI) report that 50% to 80% of extremely and very preterm neonates have diffuse white matter abnormalities (WMA) which correspond to only the minimum grade of severity. Nevertheless, mild-to-moderate diffuse WMA has also been associated with significant affectations of motor and cognitive activities. Due to increased neonatal survival and the intrinsic characteristics of diffuse WMA, there is a growing need to study the brain of the premature infant using non-invasive neuroimaging techniques sensitive to microscopic and/or diffuse lesions. This emerging need has led the scientific community to try to bridge the gap between concepts or ideas from different methodologies and approaches; for instance, neuropathology, neuroimaging and clinical findings. This is evident from the combination of intense pre-clinical and clinicopathologic research along with neonatal neurology and quantitative neuroimaging research. In the following review, we explore literature relating the most frequently observed neuropathological patterns with the recent neuroimaging findings in preterm newborns and infants with perinatal brain injury. Specifically, we focus our discussions on the use of neuroimaging to aid diagnosis, measure morphometric brain damage, and track long-term neurodevelopmental outcomes. MRI is a powerful tool for diagnosis and long-term prognosis in preterm infants. Neuropathological features of brain injury patterns are essential for MRI diagnosis. For an accurate MRI diagnosis is essential to consider the morphological evolution. Quantitative MRI provides information very helpful to long-term motor prognosis.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
3.1
作者：
Bleyenheuft Y;Dricot L;Gilis N;Kuo HC;Grandin C;Bleyenheuft C;Gordon AM;Friel KM
通讯作者：
Friel KM
影响因子：
5.1
作者：
Cheong, Jeanie L. Y.;Thompson, Deanne K.;Doyle, Lex W.
通讯作者：
Doyle, Lex W.
影响因子：
5.2
作者：
Abernethy, LJ;Palaniappan, M;Cooke, RWI
通讯作者：
Cooke, RWI
影响因子：
11.2
作者：
Back SA;Miller SP
通讯作者：
Miller SP