Development of BOLD signal hemodynamic responses in the human brain.
Development of BOLD signal hemodynamic responses in the human brain.
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DOI：
10.1016/j.neuroimage.2012.06.054
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发表时间：
2012-11-01
期刊：
影响因子：
5.7
通讯作者：
Edwards, A. David
中科院分区：
文献类型：
--
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
在啮齿动物大脑中，对短暂外部刺激的血液动力学反应在发育过程中会发生显著变化。人类婴儿的类似变化会使发育人群中功能性磁共振成像（fMRI）的血液动力学反应函数（HRF）的确定和使用变得复杂。我们旨在利用血氧水平依赖（BOLD）信号的快速采样来描述正常出生时间前后人类婴儿的HRF特征。采用体感刺激和事件相关实验设计，从10名健康成人、15名矫正月经后年龄（PMA）足月（中位数为41 + 1周）的镇静婴儿以及10名早产婴儿（中位数PMA为34 + 4周）收集数据。在所有受试者组中都识别出正振幅的HRF波形，随着年龄增长，在达到峰值时间缩短和正峰值振幅增加方面呈现出一种系统性的成熟趋势。将适合年龄的HRF模型应用于fMRI数据显著提高了fMRI分析的精度。这些发现支持了在妊娠晚期及之后大脑对刺激的反应呈结构化发育这一观点。
► 首次对人类新生儿的BOLD信号HRF进行系统性描述。
► 识别出HRF形态的成熟趋势。
► 经验性HRF模型的应用显著改善了新生儿fMRI分析。
In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the Blood Oxygen Level Dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41 + 1 weeks), and 10 preterm infants (median PMA 34 + 4 weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond. ► First systematic characterization of the BOLD signal HRF in human neonates. ► A maturational trend in HRF morphology was identified. ► Application of empirical HRF models significantly improved neonatal fMRI analysis.
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