Capturing Multicellular System Designs Using Synthetic Biology Open Language (SBOL).

Capturing Multicellular System Designs Using Synthetic Biology Open Language (SBOL).
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使用合成生物学开放语言 (SBOL) 捕获多细胞系统设计。

DOI:
10.1021/acssynbio.0c00176
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发表时间:
2020
影响因子:
4.7
通讯作者:
Brown B
Brown B
中科院分区:
生物学2区
文献类型:
--
作者:
Brown B

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合成生物学旨在开发新的生物系统,并使用标准化和模块化等工程原理提高其可重复性。重要的是,这些系统可以以标准的方式表示和共享,以确保它们可以被其他研究人员轻松理解,复制和使用。合成生物学开放语言(SBOL)是一种数据标准,用于共享生物设计及其实施和表征信息。以前,该标准仅用于表示在每个细胞中实施相同设计的系统中的设计;然而,在多细胞系统中也有很多兴趣,其中设计涉及具有不同基因型和表型的不同类型细胞的混合物。在这里,我们将展示如何使用SBOL标准来表示多细胞系统,以及研究人员如何更好地与社区共享设计并可靠地记录预期的系统功能。
Synthetic biology aims to develop novel biological systems and increase their reproducibility using engineering principles such as standardization and modularization. It is important that these systems can be represented and shared in a standard way to ensure they can be easily understood, reproduced, and utilized by other researchers. The Synthetic Biology Open Language (SBOL) is a data standard for sharing biological designs and information about their implementation and characterization. Previously, this standard has only been used to represent designs in systems where the same design is implemented in every cell; however, there is also much interest in multicellular systems, in which designs involve a mixture of different types of cells with differing genotype and phenotype. Here, we show how the SBOL standard can be used to represent multicellular systems, and, hence, how researchers can better share designs with the community and reliably document intended system functionality.
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发表时间: 2013
期刊: PloS one
影响因子: 3.7
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