Can abuse deterrent formulations make a difference? Expectation and speculation.
Can abuse deterrent formulations make a difference? Expectation and speculation.
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DOI：
10.1186/1477-7517-6-8
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发表时间：
2009-05-29
影响因子：
4.4
通讯作者：
Butler SF
中科院分区：
文献类型：
--
作者：
Budman SH;Grimes Serrano JM;Butler SF
至关重要的是，围绕处方阿片类药物滥用和误用的问题与这些药物治疗疼痛的需求相平衡。减少处方阿片类药物滥用的一种方法是开发滥用威慑配方（或adf），以某种方式防止药物滥用者提取有效成分，以便采用其他给药途径，如注射、鼻吸和吸烟。药物的药代动力学特征、药物配方的特点使其对滥用具有吸引力或不吸引力、药物滥用者的类型、成瘾途径的进展以及一个人的社会环境等几个因素都可能在处方阿片类药物的滥用以及滥用这些药物的方法中发挥作用。本文将研究这些因素，以了解它们如何影响处方阿片类药物的滥用和给药途径，以及adf的发展如何改变这些模式。
It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain. One way to decrease the abuse of prescription opioid medications is to develop abuse deterrent formulations (or ADFs) that in some way prevent drug abusers from extracting out the active ingredient in order to employ alternate routes of administration, such as injection, snorting, and smoking. Several factors including the pharmacokinetic profile of the drug, the features of the drug formulation that make it attractive or unattractive for abuse, the type of drug abuser, the progression of one's addiction pathway, and one's social environment may all play a role in the abuse of prescription opioids and what methods are used to abuse these drugs. This paper will examine these factors in order to understand how they affect the abuse of prescription opioids and routes of administration, and how the development of ADFs may alter these patterns.
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影响因子：
2.7
作者：
BALSTER, RL;SCHUSTER, CR
通讯作者：
SCHUSTER, CR
影响因子：
120.7
作者：
Hall, Aron J.;Logan, Joseph E.;Paulozzi, Leonard J.
通讯作者：
Paulozzi, Leonard J.
影响因子：
2.7
作者：
Milloy, M. -J. S.;Kerr, Thomas;Wood, Evan
通讯作者：
Wood, Evan
影响因子：
5
作者：
Katz, Nathaniel
通讯作者：
Katz, Nathaniel
影响因子：
4.4
作者：
Butler SF;Benoit C;Budman SH;Fernandez KC;McCormick C;Venuti SW;Katz N
通讯作者：
Katz N