Deficiency of the paternally inherited gene Magel2 alters the development of separation-induced vocalization and maternal behavior in mice.
Deficiency of the paternally inherited gene Magel2 alters the development of separation-induced vocalization and maternal behavior in mice.
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DOI：
10.1111/gbb.12776
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发表时间：
2022-01
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影响因子：
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后代的行为是由母本和父本基因共同表达的结果。基因组印记以一种特定的方式沉默了一些基因，在所有动物中，这一过程只发生在哺乳动物中。然而，基因组印记如何影响哺乳动物后代的行为仍然知之甚少。在这里，我们研究了小鼠幼崽中父系遗传基因Magel 2的丢失如何影响分离诱导的超声发声（USV）的发射。使用超过1000个USV的定量分析，我们表征了出生后第6-12天（P6-P12）的发声率及其光谱特征，这是小鼠发育的关键阶段，涵盖了幼鼠发声行为的峰值。我们的分析表明，Magel 2缺陷的后代以较低的速率发出分离诱导的发声，并且主要在P8处具有改变的光谱特征。我们还表明，在这个年龄段，母鼠对自己的Magel 2缺陷后代表现出改变的行为。在一项比较两只幼仔回收的测试中，母鼠首先回收野生型对照幼仔，并且比Magel 2缺陷后代更快。这些结果表明，Magel 2的缺失损害了幼鼠中分离诱导的发声的表达以及特定出生后发育年龄的母性行为，这两者都支持幼鼠的生长和发育。后代的行为是由母本和父本基因共同表达的结果。基因组印记以一种特定的方式沉默了一些基因，在所有动物中，这一过程只发生在哺乳动物中。然而，基因组印记如何影响哺乳动物后代的行为仍然知之甚少。在这里，我们报告说，Magel 2的丢失损害了小鼠幼崽中分离诱导的发声的表达以及母性行为，这两者都支持幼崽的生长和发育。
The behavior of offspring results from the combined expression of maternal and paternal genes. Genomic imprinting silences some genes in a parent‐of‐origin specific manner, a process that, among all animals, occurs only in mammals. How genomic imprinting affects the behavior of mammalian offspring, however, remains poorly understood. Here, we studied how the loss of the paternally inherited gene Magel2 in mouse pups affects the emission of separation‐induced ultrasonic vocalizations (USV). Using quantitative analysis of more than 1000 USVs, we characterized the rate of vocalizations as well as their spectral features from postnatal days 6–12 (P6–P12), a critical phase of mouse development that covers the peak of vocal behavior in pups. Our analyses show that Magel2 deficient offspring emit separation‐induced vocalizations at lower rates and with altered spectral features mainly at P8. We also show that dams display altered behavior towards their own Magel2 deficient offspring at this age. In a test to compare the retrieval of two pups, dams retrieve wildtype control pups first and faster than Magel2 deficient offspring. These results suggest that the loss of Magel2 impairs the expression of separation‐induced vocalization in pups as well as maternal behavior at a specific age of postnatal development, both of which support the pups' growth and development. The behavior of offspring results from the combined expression of maternal and paternal genes. Genomic imprinting silences some genes in a parent‐of‐origin specific manner, a process that, among all animals, occurs only in mammals. How genomic imprinting affects the behavior of mammalian offspring, however, remains poorly understood. Here we report that the loss of Magel2 impairs the expression of separation‐induced vocalization in mouse pups as well as maternal behavior, both of which support the pups' 2019; growth and development.
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DOI：
10.1111/gbb.12378
发表时间：
2017-07
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Fountain MD;Tao H;Chen CA;Yin J;Schaaf CP
通讯作者：
Schaaf CP
影响因子：
2.2
作者：
NOIROT, E
通讯作者：
NOIROT, E
影响因子：
1.9
作者：
BLUMBERG, MS;ALBERTS, JR
通讯作者：
ALBERTS, JR
影响因子：
7.2
作者：
Barlow, Denise P.;Bartolomei, Marisa S.
通讯作者：
Bartolomei, Marisa S.
影响因子：
3.5
作者：
Bischof, Jocelyn M.;Stewart, Colin L.;Wevrick, Rachel
通讯作者：
Wevrick, Rachel