BASL controls asymmetric cell division in Arabidopsis.

BASL controls asymmetric cell division in Arabidopsis.
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BASL控制拟南芥中的不对称细胞分裂。

DOI:
10.1016/j.cell.2009.04.018
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发表时间:
2009-06-26
期刊:
影响因子:
64.5
通讯作者:
Bergmann DC
Bergmann DC
中科院分区:
生物学1区
文献类型:
--
作者:
Dong J;MacAlister CA;Bergmann DC

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多细胞生物的发育需要有组织地产生差异。造成这种差异的普遍机制是不对称的细胞分裂。在植物中,和在动物中一样,不对称分裂与细胞多样性和模式的产生有关;然而,由于植物细胞壁的结构限制以及缺乏已知动物或真菌细胞极性调节因子的同源物,植物必须利用新的分子和机制来创造不对称。在这里,我们鉴定了BASL,一种新的拟南芥不对称分裂调节因子。在不对称分裂的口系细胞中,分裂前BASL在细胞外围以极化新月形聚集,分裂后在自我更新细胞及其姊妹细胞中,BASL分化地定位于细胞核和外周新月形。BASL在细胞外围的存在对其功能至关重要,我们认为BASL代表了一种植物特异性的解决方案,以应对细胞不对称分裂的挑战。
Development in multicellular organisms requires the organized generation of differences. A universal mechanism for creating such differences is asymmetric cell division. In plants, as in animals, asymmetric divisions are correlated with the production of cellular diversity and pattern; however, structural constraints imposed by plant cell walls and the absence of homologs of known animal or fungal cell polarity regulators necessitates that plants utilize new molecules and mechanisms to create asymmetries. Here, we identify BASL, a novel regulator of asymmetric divisions in Arabidopsis. In asymmetrically dividing stomatal-lineage cells, BASL accumulates in a polarized crescent at the cell periphery before division, and then localizes differentially to the nucleus and a peripheral crescent in self-renewing cells and their sisters after division. BASL presence at the cell periphery is critical for its function, and we propose that BASL represents a plant-specific solution to the challenge of asymmetric cell division.
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