Novel strategies for the treatment of chondrosarcomas: targeting integrins.
Novel strategies for the treatment of chondrosarcomas: targeting integrins.
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DOI：
10.1155/2013/396839
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发表时间：
2013
影响因子：
--
通讯作者：
Tang CH
中科院分区：
文献类型：
--
作者：
Chen JC;Fong YC;Tang CH
软骨肉瘤是一组异质性的恶性骨肿瘤，其特征在于软骨细胞外基质的产生。它们是第二种最常见的骨恶性肿瘤。手术切除仍然是软骨肉瘤的主要治疗方式，因为传统的化疗和放疗基本无效。由于缺乏有效的辅助治疗，高级别软骨肉瘤患者的治疗特别具有挑战性。整合素是调节多种细胞功能的细胞表面粘附分子。它们与实体瘤的发生、发展和转移有关。整合素表达和/或信号转导的失调已经在许多软骨肉瘤中被鉴定。因此，开发能够选择性靶向整合素基因表达和配体整合素信号传导调节剂的新药可能为治疗这些癌症带来巨大希望。在这篇综述中，我们提供了一个概述，目前的理解如何生长因子，趋化因子/细胞因子，和其他炎症相关分子可以控制特定的整合素的表达，以促进细胞迁移。我们还回顾了整合素的特定亚型及其信号传导机制的作用，并讨论了这些可能参与肿瘤生长和转移。最后，将讨论针对这些分子的新的治疗策略。
Chondrosarcomas are a heterogeneous group of malignant bone tumors that are characterized by the production of cartilaginous extracellular matrix. They are the second most frequently occurring type of bone malignancy. Surgical resection remains the primary mode of treatment for chondrosarcomas, since conventional chemotherapy and radiotherapy are largely ineffective. Treatment of patients with high-grade chondrosarcomas is particularly challenging, owing to the lack of effective adjuvant therapies. Integrins are cell surface adhesion molecules that regulate a variety of cellular functions. They have been implicated in the initiation, progression, and metastasis of solid tumors. Deregulation of integrin expression and/or signaling has been identified in many chondrosarcomas. Therefore, the development of new drugs that can selectively target regulators of integrin gene expression and ligand-integrin signaling might hold great promise for the treatment of these cancers. In this review, we provide an overview of the current understanding of how growth factors, chemokines/cytokines, and other inflammation-related molecules can control the expression of specific integrins to promote cell migration. We also review the roles of specific subtypes of integrins and their signaling mechanisms, and discuss how these might be involved in tumor growth and metastasis. Finally, novel therapeutic strategies for targeting these molecules will be discussed.
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DOI：
10.1302/0301-620x.87b11.16621
发表时间：
2005-11-01
影响因子：
--
作者：
Donati, D;El Ghoneimy, A;Mercuri, M
通讯作者：
Mercuri, M
影响因子：
5.6
作者：
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影响因子：
2.7
作者：
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通讯作者：
Baptista, André Mathias
影响因子：
5.8
作者：
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通讯作者：
Bovee, Judith V. M. G.
影响因子：
3.3
作者：
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通讯作者：
Lackman, R