Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women.
Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women.
复制标题
DOI：
10.1002/nau.24707
复制
发表时间：
2021-08
影响因子：
2
通讯作者：
Brubaker L
中科院分区：
文献类型：
--
作者：
Burnett LA;Hochstedler BR;Weldon K;Wolfe AJ;Brubaker L
复发性尿路感染（鲁蒂）妇女的临床特征与其尿液微生物相关。这项IRB批准的横断面研究招募了患有鲁蒂的成年女性。通过扩展定量尿培养（EQUC）和标准尿培养（SUC）方法对尿液样本（插入导管和排泄）进行培养。使用经验证的症状问卷、相关临床变量和EQUC来识别症状群并检测与特定尿液微生物的相关性。大多数（36/43）参与者绝经后;平均年龄为67岁。51%报告阴道雌激素使用; 51%报告性活动。虽然单一症状与特定的尿液微生物无关，但EQUC结果与五个不同的临床特征集群相关：A组：气味，浑浊和当前阴道雌激素使用（无培养结果相关性）。B组：频率、腰痛、排空不完全和阴道雌激素（乳酸杆菌阳性培养物的比例显著增加）。C组：疼痛/烧灼感、气味、浑浊和紧迫感（高比例的UTI相关微生物阳性培养物）。D组：频率、紧迫性、疼痛/烧灼感和当前阴道雌激素使用（无生长培养物数量增加）。E组：频率、紧迫感、疼痛/灼烧感、气味、膀胱过度活动症和性活跃（克雷伯氏菌阳性培养物的比例显着增加）。不同的临床特征与鲁蒂妇女的特定泌尿微生物相关。对临床特征的精确评估可以提供有用的见解，可以为诊断和治疗考虑提供信息。
Clinical profiles of women with recurrent urinary tract infection (RUTI) are correlated with their urinary microbes. This IRB-approved, cross-sectional study enrolled adult women with RUTI. Urine samples (catheterized and voided) underwent culture by expanded quantitative urine culture (EQUC) and standard urine culture (SUC) methods. A validated symptom questionnaire, relevant clinical variables and EQUC were used to identify symptom clusters and detect associations with specific urinary microbes. Most (36/43) participants were postmenopausal; the average age was 67 years. 51% reported vaginal estrogen use; 51% reported sexual activity. Although single symptoms were not associated with specific urinary microbes, EQUC results were correlated with five distinct clinical profile clusters: Group A: odor, cloudiness, and current vaginal estrogen use (no culture result association). Group B: frequency, low back pain, incomplete emptying, and vaginal estrogen (significantly increased proportion of Lactobacillus-positive cultures). Group C: pain/burning, odor, cloudiness, and urgency (high proportions of UTI-associated microbe-positive cultures). Group D: frequency, urgency, pain/burning, and current vaginal estrogen use (increased number of no growth cultures). Group E: frequency, urgency, pain/burning, odor, overactive bladder, and sexually active (significantly increased proportion of Klebsiella-positive cultures). Distinct clinical profiles are associated with specific urinary microbes in women with RUTI. Refined assessments of clinical profiles may provide useful insights that could inform diagnostic and therapeutic considerations.
登录
查看更多内容
DOI：
10.1016/j.ejogrb.2017.04.040
发表时间：
2017-07-01
影响因子：
2.6
作者：
Curtiss, Natasha;Balachandran, Aswini;Duckett, Jonathan
通讯作者：
Duckett, Jonathan
阴道雌激素疗法与绝经后妇女的尿液中乳酸杆菌升高有关，患有过度活跃的膀胱症状。
影响因子：
9.8
作者：
Thomas-White K;Taege S;Limeira R;Brincat C;Joyce C;Hilt EE;Mac-Daniel L;Radek KA;Brubaker L;Mueller ER;Wolfe AJ
通讯作者：
Wolfe AJ
影响因子：
9.4
作者：
Sathiananthamoorthy, Sanchutha;Malone-Lee, James;Rohn, Jennifer L.
通讯作者：
Rohn, Jennifer L.
影响因子：
64.8
作者：
Surana NK;Kasper DL
通讯作者：
Kasper DL
影响因子：
1.8
作者：
Hochstedler BR;Burnett L;Price TK;Jung C;Wolfe AJ;Brubaker L
通讯作者：
Brubaker L