Serum and urine biomarkers for human renal cell carcinoma.

Serum and urine biomarkers for human renal cell carcinoma.
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DOI:
10.1155/2015/251403
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发表时间:
2015
期刊:
影响因子:
--
通讯作者:
Di Carlo A
Di Carlo A
中科院分区:
医学4区
文献类型:
--
作者:
Pastore AL;Palleschi G;Silvestri L;Moschese D;Ricci S;Petrozza V;Carbone A;Di Carlo A

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肾细胞癌(RCC)的诊断大多是偶然通过成像提供无关的临床原因。局部肿瘤的手术治疗已报告了极好的结果。近年来,随着所谓的“靶向治疗”的广泛使用,晚期RCC的治疗已经有了相当大的发展。体液中分子标志物的鉴定(例如,血清和尿液),其可用于RCC患者中的筛选、诊断、随访和基于药物的治疗的监测,是肿瘤学研究中最雄心勃勃的挑战之一。虽然有一些关于血清中潜在生物标志物的有希望的报告,但关于RCC的尿液标志物的可用数据有限。以下综述报告了在RCC患者的生物体液中鉴定的一些最有希望的生物标志物。
Renal cell carcinoma (RCC) diagnosis is mostly achieved incidentally by imaging provided for unrelated clinical reasons. The surgical management of localized tumors has reported excellent results. The therapy of advanced RCC has evolved considerably over recent years with the widespread use of the so-called “targeted therapies.” The identification of molecular markers in body fluids (e.g., sera and urine), which can be used for screening, diagnosis, follow-up, and monitoring of drug-based therapy in RCC patients, is one of the most ambitious challenges in oncologic research. Although there are some promising reports about potential biomarkers in sera, there is limited available data regarding urine markers for RCC. The following review reports some of the most promising biomarkers identified in the biological fluids of RCC patients.
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