Flexible Mx specification of various extended twin kinship designs.
Flexible Mx specification of various extended twin kinship designs.
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DOI：
10.1375/twin.12.1.26
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Eaves LJ
中科院分区：
文献类型：
--
作者：
Maes HH;Neale MC;Medland SE;Keller MC;Martin NG;Heath AC;Eaves LJ
扩展的双胞胎亲属设计允许同时测试加性和非加性遗传，共享和个人特定的环境因素，以及性别差异的基因和环境的表达，在存在的替代交配和遗传和文化相结合的传输。它还处理这些变异源对多个表型的（共）变异的贡献。Keller等人（2008年）扩展了这一全面的家族相似性模型，以允许灵活的分类和垂直传播规范。因此，它提供了一个通用的框架，可以很容易地减少，以适应数据的子集，如双胞胎父母的数据，双胞胎的孩子的数据，等一个灵活的Mx规格的这个模型，允许处理这些各种设计的详细介绍，并适用于数据从弗吉尼亚州30000。从双胞胎及其家庭中获得了身高、体重指数、吸烟状况、教堂出勤率和政治派别的数据。结果表明，方差分量估计的偏差既取决于可用于分析的相对类型，也取决于感兴趣的表型的潜在遗传和环境结构。
The extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission. It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest.
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影响因子：
0.9
作者：
Medland, Sarah E.;Keller, Matthew C.
通讯作者：
Keller, Matthew C.
DOI：
10.1375/136905299320566031
发表时间：
1999-06-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Maes, H H;Neale, M C;Eaves, L J
通讯作者：
Eaves, L J
影响因子：
2.6
作者：
TRUETT, KR;EAVES, LJ;KENDLER, KS
通讯作者：
KENDLER, KS
影响因子：
2.6
作者：
HEATH, AC;EAVES, LJ
通讯作者：
EAVES, LJ
DOI：
10.1375/twin.12.1.8
发表时间：
2009-02
期刊：
Twin research and human genetics : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Keller MC;Medland SE;Duncan LE;Hatemi PK;Neale MC;Maes HH;Eaves LJ
通讯作者：
Eaves LJ