Computational model of whole blood exhibiting lateral platelet motion induced by red blood cells.

Computational model of whole blood exhibiting lateral platelet motion induced by red blood cells.
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DOI:
10.1002/cnm.1274
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发表时间:
2010-03-01
影响因子:
2.1
通讯作者:
Fogelson AL
Fogelson AL
中科院分区:
工程技术3区
文献类型:
--
作者:
Crowl LM;Fogelson AL

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本文发展了一种浸没边界方法,其中流体的运动是用格子Boltzmann方法计算的。该方法适用于探索实验观察到的横向再分布的血小板和血小板大小的颗粒在浓缩的悬浮液中的红细胞进行通道流。模拟捕获红细胞诱导的血小板横向运动和随后的血小板浓度分布的发展,包括在几微米的通道壁内的浓度增加。在模拟中,从红细胞的随机分布和血小板大小的颗粒的均匀分布开始,近壁增强浓度在大约400毫秒内发展。
An Immersed Boundary method is developed in which the fluid's motion is calculated using the lattice Boltzmann method. The method is applied to explore the experimentally-observed lateral redistribution of platelets and platelet-sized particles in concentrated suspensions of red blood cells undergoing channel flow. Simulations capture red-blood-cell-induced lateral platelet motion and the consequent development of a platelet concentration profile that includes an enhanced concentration within a few microns of the channel walls. In the simulations, the near-wall enhanced concentration develops within approximately 400 msec starting from a random distribution of red blood cells and a uniform distribution of platelet-sized particles.
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