Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents.
Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents.
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DOI：
10.1016/j.bbi.2009.02.017
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发表时间：
2009-08
影响因子：
15.1
通讯作者：
Postolache, Teodor T.
中科院分区：
文献类型：
--
作者：
Tonelli, Leonardo H.;Katz, Morgan;Kovacsics, Colleen E.;Gould, Todd D.;Joppy, Belzora;Hoshino, Akina;Hoffman, Gloria;Komarow, Hirsh;Postolache, Teodor T.
流行病学和临床研究报告，患有呼吸道过敏的个体焦虑和情绪反应增加的发生率更高。为了评估呼吸道过敏是否能够促进啮齿动物的焦虑样行为，我们使用了过敏性鼻炎模型和行为评估，然后评估相关脑区细胞因子的mRNA。按照标准致敏和激发方案，小鼠和大鼠分别对卵清蛋白或花粉致敏。攻击后，在旷场、高架十字迷宫和常驻入侵者测试中对动物进行评价。细胞因子和促肾上腺皮质激素释放因子的表达进行了评估，在几个大脑区域的实时RT-PCR和血浆皮质类固醇浓度的放射免疫法。致敏并暴露于过敏原的小鼠和大鼠表现出焦虑样行为增加，社会互动减少，但没有任何明显的疾病行为体征。辅助性T细胞2型（TH 2）细胞因子在大鼠和小鼠的嗅球和前额叶皮层中诱导，在颞叶皮层和下丘脑中保持不变。CRFmRNA表达也有相同的结果。最后一次行为测试后1小时，皮质酮浓度无差异。这些结果表明，致敏和过敏原的挑战诱导焦虑的啮齿动物物种，这些影响是由增加的表达的TH 2细胞因子和CRF在前额皮质。这些研究提供了实验证据，证明致敏啮齿动物经历神经免疫介导的焦虑和与过敏性鼻炎相关的社会互动减少。
Epidemiological and clinical studies report higher incidences of anxiety and increased emotional reactivity in individuals suffering from respiratory allergies. To evaluate if respiratory allergies are capable of promoting anxiety-like behavior in rodents, we used models of allergic rhinitis and behavioral evaluations followed by assessment of mRNA for cytokines in relevant brain regions. Mice and rats were sensitized to ovoalbumin or pollen respectively following standard sensitization and challenge protocols. After challenge, the animals were evaluated in the open field, elevated plus maze and resident intruder tests. Cytokines and corticotropin releasing factor expression were assessed in several brain regions by real-time RT-PCR and plasma corticostereone concentrations by radioimmunoassay. Mice and rats sensitized and exposed to allergen showed increased anxiety-like behavior and reduced social interaction without any overt behavioral signs of sickness. T-helper type 2 (TH2) cytokines were induced in both rats and mice in the olfactory bulbs and prefrontal cortex and remained unchanged in the temporal cortex and hypothalamus. The same results were found for CRF mRNA expression. No differences were observed in corticosterone concentrations one hour after the last behavioral test. These results show that sensitization and challenge with allergens induce anxiety across rodent species and that these effects were paralleled by an increased expression of TH2 cytokines and CRF in the prefrontal cortex. These studies provide experimental evidence that sensitized rodents experience neuroimmune-mediated anxiety and reduced social interaction associated with allergic rhinitis.
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影响因子：
10.6
作者：
Drevets, WC
通讯作者：
Drevets, WC
DOI：
10.1196/annals.1366.028
发表时间：
2006-01-01
期刊：
NEUROENDOCRINE AND IMMUNE CROSSTALK
影响因子：
--
作者：
Costa-Pinto, Frederico Azevedo;Basso, Alexandre Salgado;Palermo-Neto, Joao
通讯作者：
Palermo-Neto, Joao
影响因子：
2.8
作者：
Blaiss, Michael S.
通讯作者：
Blaiss, Michael S.
影响因子：
3.1
作者：
Barone, Silvana;Bacon, Simon L.;Lavoie, Kim L.
通讯作者：
Lavoie, Kim L.
影响因子：
5
作者：
Hurwitz, EL;Morgenstern, H
通讯作者：
Morgenstern, H