MicroRNA Changes in Preconditioning-Induced Neuroprotection.
MicroRNA Changes in Preconditioning-Induced Neuroprotection.
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DOI：
10.1007/s12975-017-0547-1
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发表时间：
2017-12
影响因子：
6.9
通讯作者：
Giffard RG
中科院分区：
文献类型：
--
作者：
Bell JD;Cho JE;Giffard RG
预处理是一种范式，其中亚致死压力-在更有害的侮辱之前-诱导对伤害的保护。在中枢神经系统（CNS）中，对缺血性中风的预适应是由短时间缺血、短暂癫痫发作、暴露于麻醉剂和其他应激引起的。越来越多的证据支持microRNAs （miRNAs）在脑缺血和预适应诱导的缺血耐受的发病机制中的作用。迄今为止，研究预处理诱导的miRNA变化的研究已经确定了562种miRNA在预处理后改变表达水平，其中15%的变化在至少一项额外的研究中得到了再现。在不止一项研究中被预适应改变的mirna中，约40%在不止一项研究中发生了相同方向的变化。大多数评估特异性mirna在预处理神经保护机制中的作用的研究都是在体外进行的，很少有研究在体内操纵单个mirna。因此，虽然许多mirna会响应预处理刺激而发生变化，但其作用的机制尚不清楚。这些数据确实表明，mirna可能在预处理诱导的神经保护中发挥重要作用。本文综述了mirna在预调节诱导的脑保护中可能发挥的作用。
Preconditioning is a paradigm in which sub-lethal stress – prior to a more injurious insult – induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evidence supports the contribution of microRNAs (miRNAs) to the pathogenesis of cerebral ischemia and ischemic tolerance induced by preconditioning. Studies investigating miRNA changes induced by preconditioning have to date identified 562 miRNAs that change expression levels after preconditioning, and 15% of these changes were reproduced in at least one additional study. Of miRNAs assessed as changed by preconditioning in more than one study, about 40% changed in the same direction in more than one study. Most of the studies to assess the role of specific miRNAs in the neuroprotective mechanism of preconditioning were performed in vitro, with fewer studies manipulating individual miRNAs in vivo. Thus, while many miRNAs change in response to preconditioning stimuli, the mechanisms underlying their effects are not well understood. The data does suggest that miRNAs may play significant roles in preconditioning-induced neuroprotection. This review focuses on the current state of knowledge of the possible role of miRNAs in preconditioning-induced cerebral protection.
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DOI：
10.1038/jcbfm.2008.157
发表时间：
2009-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
影响因子：
4
作者：
Cardoso, Ana L.;Guedes, Joana R.;Pedroso de Lima, Maria C.
通讯作者：
Pedroso de Lima, Maria C.
DOI：
10.1111/j.1742-4658.2010.07818.x
发表时间：
2010-10
期刊：
The FEBS journal
影响因子：
--
作者：
Buller B;Liu X;Wang X;Zhang RL;Zhang L;Hozeska-Solgot A;Chopp M;Zhang ZG
通讯作者：
Zhang ZG
影响因子：
5.3
作者：
Ardelt, Agnieszka A.;Bhattacharyya, Bula J.;Belmadani, Abdelhak;Ren, Dongun;Miller, Richard J.
通讯作者：
Miller, Richard J.