Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair.
Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair.
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DOI：
10.1016/j.expneurol.2013.06.017
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发表时间：
2013-10
影响因子：
5.3
通讯作者：
Miller, Richard J.
中科院分区：
文献类型：
--
作者：
Ardelt, Agnieszka A.;Bhattacharyya, Bula J.;Belmadani, Abdelhak;Ren, Dongun;Miller, Richard J.
为了应对缺血性损伤，大脑启动修复过程，涉及新神经元、少突胶质细胞和星形胶质细胞的发育。然而，新神经元整合到现有大脑回路的方式尚不清楚。在这里，我们观察到，在短暂性大脑中动脉闭塞（MCAO）后的四个星期内，源自室下区（SVZ）的表达双皮质素（DCX）的神经祖细胞出现在缺血性病变边界区，在那里它们接受γ-氨基丁酸（GABA）输入，这是新发育的神经元的常见特征。短暂性 MCAO 后长达 4 周内，趋化因子基质衍生因子 1（SDF-1 或 CXCL12）在病变内皮细胞和小胶质细胞中富集，将 SDF-1 应用于急性脑切片可增强对新神经元的 GABA 能输入。这些观察结果表明，SDF-1 在脑缺血再灌注后的修复过程中能够协调新血管形成和神经发生。
In response to ischemic injury, the brain mounts a repair process involving the development of new neurons, oligodendrocytes, and astrocytes. However, the manner in which new neurons integrate into existing brain circuitry is not well understood. Here we observed that during the four weeks after transient middle cerebral artery occlusion (MCAO), doublecortin (DCX)-expressing neural progenitors originating in the subventricular zone (SVZ) were present in the ischemic lesion borderzone, where they received γ-aminobutyric acid (GABA) inputs, a feature that is common to newly developing neurons. The chemokine stromal derived factor-1 (SDF-1 or CXCL12) was enriched in lesional endothelial and microglial cells for up to four weeks after transient MCAO, and application of SDF-1 to acute brain slices enhanced GABAergic inputs to the new neurons. These observations suggest that SDF-1 is in a position to coordinate neovascularization and neurogenesis during the repair process after cerebral ischemia-reperfusion.
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影响因子：
5.3
作者：
Ohab, John J.;Fleming, Sheila;Carmichael, S. Thomas
通讯作者：
Carmichael, S. Thomas
DOI：
10.1073/pnas.95.16.9448
发表时间：
1998-08-04
影响因子：
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影响因子：
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作者：
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影响因子：
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作者：
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