An evidence-based comparison of operational criteria for the presence of sarcopenia.
An evidence-based comparison of operational criteria for the presence of sarcopenia.
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DOI：
10.1093/gerona/glu013
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Studenski S
中科院分区：
文献类型：
--
作者：
Dam TT;Peters KW;Fragala M;Cawthon PM;Harris TB;McLean R;Shardell M;Alley DE;Kenny A;Ferrucci L;Guralnik J;Kiel DP;Kritchevsky S;Vassileva MT;Studenski S
几个共识小组先前已经公布了肌肉减少症的操作标准，将瘦体重与力量和/或身体表现相结合。本手稿的目的是描述美国国立卫生研究院基金会（FNIH）标准与其他肌肉减少症操作定义之间的患病率、一致性和差异。FNIH Sarcopenia项目使用了来自九项研究的数据，包括：年龄，基因和环境易感性-雷克雅未克研究;波士顿波多黎各健康研究;康涅狄格大学的一系列六项临床试验;心脏病研究;健康，衰老和身体成分研究; Invecchiare in Chianti;男性骨质疏松性骨折研究; Rancho Bernardo研究;和骨质疏松性骨折研究。这些分析中包括的参与者年龄在65岁及以上，并测量了体重指数，apapapricular瘦体重，握力和步态速度。女性肌肉减少症的患病率和同意比例高于男性。与国际工作组和欧洲老年人肌肉减少症工作组（男性分别为5.1%和5.3%，女性分别为11.8%和13.3%）相比，FNIH标准的患病率最低（男性1.3%，女性2.3%）。FNIH标准与其他标准之间的阳性百分比一致率较低，男性为7%至32%，女性为5%至19%。然而，阴性一致率很高（均> 95%）。FNIH标准导致肌肉减少症的操作定义更保守，并且与其他建议的标准相比，患病率较低。诊断肌肉减少症的一致性较低，但排除肌肉减少症的一致性非常高。肌肉减少症的诊断操作标准的共识是非常需要的研究人群的特点，并确定成人治疗。
Several consensus groups have previously published operational criteria for sarcopenia, incorporating lean mass with strength and/or physical performance. The purpose of this manuscript is to describe the prevalence, agreement, and discrepancies between the Foundation for the National Institutes of Health (FNIH) criteria with other operational definitions for sarcopenia. The FNIH Sarcopenia Project used data from nine studies including: Age, Gene and Environment Susceptibility-Reykjavik Study; Boston Puerto Rican Health Study; a series of six clinical trials from the University of Connecticut; Framingham Heart Study; Health, Aging, and Body Composition Study; Invecchiare in Chianti; Osteoporotic Fractures in Men Study; Rancho Bernardo Study; and Study of Osteoporotic Fractures. Participants included in these analyses were aged 65 and older and had measures of body mass index, appendicular lean mass, grip strength, and gait speed. The prevalence of sarcopenia and agreement proportions was higher in women than men. The lowest prevalence was observed with the FNIH criteria (1.3% men and 2.3% women) compared with the International Working Group and the European Working Group for Sarcopenia in Older Persons (5.1% and 5.3% in men and 11.8% and 13.3% in women, respectively). The positive percent agreements between the FNIH criteria and other criteria were low, ranging from 7% to 32% in men and 5% to 19% in women. However, the negative percent agreement were high (all >95%). The FNIH criteria result in a more conservative operational definition of sarcopenia, and the prevalence was lower compared with other proposed criteria. Agreement for diagnosing sarcopenia was low, but agreement for ruling out sarcopenia was very high. Consensus on the operational criteria for the diagnosis of sarcopenia is much needed to characterize populations for study and to identify adults for treatment.
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DOI：
10.1093/gerona/56.5.m266
发表时间：
2001-05-01
影响因子：
5.1
作者：
Kenny, AM;Prestwood, KM;Raisz, LG
通讯作者：
Raisz, LG
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
6.7
作者：
Landi, Francesco;Cruz-Jentoft, Alfonso J.;Onder, Graziano
通讯作者：
Onder, Graziano
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
影响因子：
6.7
作者：
Patel HP;Syddall HE;Jameson K;Robinson S;Denison H;Roberts HC;Edwards M;Dennison E;Cooper C;Aihie Sayer A
通讯作者：
Aihie Sayer A