Altered short-term plasticity in the prefrontal cortex after early life seizures.
Altered short-term plasticity in the prefrontal cortex after early life seizures.
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DOI：
10.1016/j.nbd.2012.10.007
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发表时间：
2013-02
影响因子：
6.1
通讯作者：
Isaeva E
中科院分区：
文献类型：
--
作者：
Hernan AE;Holmes GL;Isaev D;Scott RC;Isaeva E
发育期间的癫痫发作相对常见，通常与认知结果不良有关。最近的研究表明，生命早期癫痫发作改变了各种大脑结构的功能，并对癫痫发作易感性和行为调节产生长期影响。虽然许多新皮层功能可能被癫痫发作破坏，但我们集中研究了前额叶皮层（PFC），因为PFC功能的紊乱涉及许多与癫痫相关的共病疾病。在目前的工作中，我们报告的PFC在经历了生命早期癫痫发作的大鼠短期可塑性的改变。最稳健的改变发生在神经元的第II/III层到第V层网络中。然而，V层到V层网络的短期可塑性也受到影响，表明PFC功能受到早期癫痫发作的广泛影响。这些数据有力地表明，反复发作的早期发展造成实质性改变PFC功能，这可能是一个重要组成部分，在发展过程中的癫痫发作史的个人的认知缺陷。
Seizures during development are a relatively common occurrence and are often associated with poor cognitive outcomes. Recent studies show that early life seizures alter the function of various brain structures and have long-term consequences on seizure susceptibility and behavioral regulation. While many neocortical functions could be disrupted by epileptic seizures we have concentrated on studying the prefrontal cortex (PFC) as disturbance of PFC functions is involved in numerous co-morbid disorders associated with epilepsy. In the present work we report an alteration of short-term plasticity in the PFC in rats that have experienced early life seizures. The most robust alteration occurs in the layer II/III to layer V network of neurons. However short-term plasticity of layer V to layer V network was also affected, indicating that the PFC function is broadly influenced by early life seizures. These data strongly suggest that repetitive seizures early in development cause substantial alteration in PFC function, which may be an important component underlying cognitive deficits in individuals with a history of seizures during development.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1002333107
发表时间：
2010-04-20
影响因子：
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作者：
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通讯作者：
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