Dopamine facilitates the translation of physical exertion into assessments of effort.
Dopamine facilitates the translation of physical exertion into assessments of effort.
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DOI：
10.1038/s41531-023-00490-4
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发表时间：
2023-04-01
影响因子：
8.7
通讯作者：
Chib, Vikram S.
中科院分区：
文献类型：
--
作者：
Padmanabhan, Purnima;Casamento-Moran, Agostina;Kim, Aram;Gonzalez, Anthony J.;Pantelyat, Alexander;Roemmich, Ryan T.;Chib, Vikram S.
我们对努力的评估是由努力的经验决定的。然而，目前还不清楚神经系统如何将体力消耗转化为对努力的评估。神经调节剂多巴胺的可用性影响运动表现和基于努力的决策的特征。为了测试多巴胺在将努力消耗转化为努力评估中的作用，我们让帕金森病参与者在多巴胺耗尽（关闭多巴胺能药物）和升高（多巴胺能药物）状态下进行体力消耗水平并回顾性评估他们付出了多少努力。与补充多巴胺的状态相比，在多巴胺耗尽的状态下，参与者表现出增加的运动变异性，并过度报告了他们的运动水平。增加的运动变异性与不太准确的努力评估有关，多巴胺对这种影响有保护作用，降低了运动变异性破坏努力评估的程度。我们的研究结果提供了一个帐户的多巴胺的作用，在翻译功能的运动表现为判断的努力，和一个潜在的治疗目标的增加的努力感观察到的范围内的神经和精神疾病。
Our assessments of effort are critically shaped by experiences of exertion. However, it is unclear how the nervous system transforms physical exertion into assessments of effort. Availability of the neuromodulator dopamine influences features of motor performance and effort-based decision-making. To test dopamine’s role in the translation of effortful exertion into assessments of effort, we had participants with Parkinson’s disease, in dopamine depleted (OFF dopaminergic medication) and elevated (ON dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. In a dopamine-depleted state, participants exhibited increased exertion variability and over-reported their levels of exertion, compared to the dopamine-supplemented state. Increased exertion variability was associated with less accurate effort assessment and dopamine had a protective influence on this effect, reducing the extent to which exertion variability corrupted assessments of effort. Our findings provide an account of dopamine’s role in the translation of features of motor performance into judgments of effort, and a potential therapeutic target for the increased sense of effort observed across a range of neurologic and psychiatric conditions.
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影响因子：
5.3
作者：
Hu, Eric J.;Casamento-Moran, Agostina;Chib, Vikram S.
通讯作者：
Chib, Vikram S.
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Wolpert, DM