Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease.
Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease.
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重度抑郁症与非酒精性脂肪肝的相互作用机制
DOI：
10.3389/fpsyt.2021.711835
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Shao Q;Wu Y;Ji J;Xu T;Yu Q;Ma C;Liao X;Cheng F;Wang X
重度抑郁障碍(MDD)与非酒精性脂肪性肝病(NAFLD)密切相关，其发病机制复杂。然而，少数研究评估了MDD和NAFLD发展过程中相互作用的病理机制。慢性应激介导的糖皮质激素(GC)水平升高在MDD相关NAFLD的发生发展中起着重要作用。GC水平升高会导致炎症因子的释放和肠道通透性的改变。炎症因子水平的升高激活了下丘脑-垂体-肾上腺(HPA)轴，进一步增加了GC的释放。同时，肠道通透性的变化促进炎症因子的释放，导致三者之间的恶性循环，导致疾病爆发。尽管甲状腺激素(TH)在这一发病机制中的具体作用尚未完全确定，但它与MDD和NAFLD高度相关。因此，改变生活方式、降低心理应激水平是预防MDD相关NAFLD的必要措施。其中，GC抑制剂和受体拮抗剂可能是减缓早、中期疾病进展的关键。然而，联合用药在晚期疾病中可能很重要，但它们与各种副作用有关。中医药已被证明是治疗这种复杂疾病的潜在选择。
Major depressive disorder (MDD), which is highly associated with non-alcoholic fatty liver disease (NAFLD), has complex pathogenic mechanisms. However, a limited number of studies have evaluated the mutual pathomechanisms involved in MDD and NAFLD development. Chronic stress-mediated elevations in glucocorticoid (GC) levels play an important role in the development of MDD-related NAFLD. Elevated GC levels can induce the release of inflammatory factors and changes in gut permeability. Elevated levels of inflammatory factors activate the hypothalamic–pituitary–adrenal (HPA) axis, which further increases the release of GC. At the same time, changes in gut permeability promote the release of inflammatory factors, which results in a vicious circle among the three, causing disease outbreaks. Even though the specific role of the thyroid hormone (TH) in this pathogenesis has not been fully established, it is highly correlated with MDD and NAFLD. Therefore, changing lifestyles and reducing psychological stress levels are necessary measures for preventing MDD-related NAFLD. Among them, GC inhibitors and receptor antagonists may be key in the alleviation of early and mid-term disease progression. However, combination medications may be important in late-stage diseases, but they are associated with various side effects. Traditional Chinese medicines have been shown to be potential therapeutic alternatives for such complex diseases.
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影响因子：
4.3
作者：
Asaoka Y;Terai S;Sakaida I;Nishina H
通讯作者：
Nishina H
影响因子：
3.8
作者：
Canas-Gonzalez, Beatriz;Fernandez-Nistal, Alonso;Martinez-Fernandez, Vicente
通讯作者：
Martinez-Fernandez, Vicente
影响因子：
3.7
作者：
Anacker, Christoph;Zunszain, Patricia A.;Carvalho, Livia A.;Pariante, Carmine M.
通讯作者：
Pariante, Carmine M.
影响因子：
4.1
作者：
Al-Khelaifi, Fatima;Donati, Francesco;Elrayess, Mohamed A.
通讯作者：
Elrayess, Mohamed A.
影响因子：
4.8
作者：
Bruder-Nascimento T;da Silva MA;Tostes RC
通讯作者：
Tostes RC