The relationship between mental retardation and developmental delays in children and the levels of arsenic, mercury and lead in soil samples taken near their mother's residence during pregnancy.

The relationship between mental retardation and developmental delays in children and the levels of arsenic, mercury and lead in soil samples taken near their mother's residence during pregnancy.
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DOI:
10.1016/j.ijheh.2009.12.004
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发表时间:
2010-03
影响因子:
6
通讯作者:
Aelion, C. Marjorie
Aelion, C. Marjorie
中科院分区:
医学2区
文献类型:
--
作者:
Liu, Yuan;McDermott, Suzanne;Lawson, Andrew;Aelion, C. Marjorie

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本研究的目的是评估铅,汞,砷在孕妇住所附近的土壤中,在怀孕期间和儿童的智力迟钝或发育障碍(MR/DD)之间的关联。这项研究是在1997年1月1日至2002年12月31日期间对6,048名母亲进行的,这些母亲在怀孕期间没有搬家,住在南卡罗来纳州的六个狭长地带内,并由医疗补助保险。然后,通过他们的医疗补助报销文件,对母亲和孩子进行随访,直到2008年6月1日,以确定诊断为MR/DD的儿童。土壤中的汞(Hg),铅(Pb),和作为一个统一的网格的基础上采样,土壤浓度克立格估计在个别地点的化学浓度。我们确定了一个显着的关系MR/DD和作为,和形式的关系是非线性的,在控制其他已知的危险因素。
This study was designed to evaluate the association between lead, mercury, and arsenic in the soil near maternal residences during pregnancy and mental retardation or developmental disability (MR/DD) in children. The study was conducted using 6,048 mothers who did not move throughout their pregnancies and lived within six strips of land in South Carolina and were insured by Medicaid between January 1, 1997 and December 31, 2002. The mother child pairs were then followed until June 1, 2008, through their Medicaid reimbursement files, to identify children diagnosed with MR/DD. The soil was sampled for mercury (Hg), lead (Pb), and As based on a uniform grid, and the soil concentrations were Kriged to estimate chemical concentration at individual locations. We identified a significant relationship between MR/DD and As, and the form of the relationship was nonlinear, after controlling for other known risk factors.
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