Osteoprotegerin as a marker of atherosclerosis in diabetic patients.
Osteoprotegerin as a marker of atherosclerosis in diabetic patients.
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DOI：
10.1155/2013/182060
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发表时间：
2013
影响因子：
2.8
通讯作者：
Creatsas G
中科院分区：
文献类型：
--
作者：
Augoulea A;Vrachnis N;Lambrinoudaki I;Dafopoulos K;Iliodromiti Z;Daniilidis A;Varras M;Alexandrou A;Deligeoroglou E;Creatsas G
动脉粥样硬化是心血管疾病（CVD）的主要原因，并有许多危险因素，其中包括糖尿病。骨保护素（OPG）是一种可溶性糖蛋白，参与骨代谢。OPG也存在于其他组织中，研究表明它在血管平滑肌细胞中表达。OPG与各种炎症有关，也与糖尿病有关。糖尿病和血糖控制不良患者血清OPG水平升高。此外，青春期前患有1型糖尿病的儿童OPG水平显着增加。核因子κ B配体受体激活因子（RANKL）在正常情况下不存在于血管系统中，但可能出现在钙化区域。OPG和RANKL是骨和血管组织中矿物质代谢的重要调节剂。关于血浆OPG/RANKL水平与内皮功能障碍之间的关系，使用超声指数等非侵入性方法评估的数据很少，无论是在一般人群中，还是更具体地说，在糖尿病患者中。我们的回顾性研究的目的是调查，根据现有的数据，这些相互关系，以确定一种方法来预测，通过非侵入性的方法，以后的发展内皮功能障碍和血管并发症的糖尿病患者。
Atherosclerosis is the principal cause of cardiovascular disease (CVD) and has many risk factors, among which is diabetes. Osteoprotegerin (OPG) is a soluble glycoprotein, involved in bone metabolism. OPG is also found in other tissues, and studies have shown that it is expressed in vascular smooth muscle cells. OPG has been implicated in various inflammations and also has been linked to diabetes mellitus. Increased serum OPG levels were found in patients with diabetes and poor glycemic control. Furthermore, prepubertal children with type 1 diabetes have significantly increased OPG levels. Receptor activator of nuclear factor kappa-B ligand (RANKL) is not found in the vasculature in normal conditions, but may appear in calcifying areas. OPG and RANKL are important regulators of mineral metabolism in both bone and vascular tissues. Few data are available on the relationship between plasma OPG/RANKL levels and endothelial dysfunction as assessed using noninvasive methods like ultrasound indexes, neither in the general population nor, more specifically, in diabetic patients. The aim of our review study was to investigate, based on the existing data, these interrelationships in order to identify a means of predicting, via noninvasive methods, later development of endothelial dysfunction and vascular complications in diabetic patients.
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影响因子：
37.8
作者：
Davis, PH;Dawson, JD;Lauer, RM
通讯作者：
Lauer, RM
DOI：
10.1161/01.atv.0000236428.91125.e6
发表时间：
2006-09-01
影响因子：
8.7
作者：
Bennett, Brian J.;Scatena, Marta;Rosenfeld, Michael E.
通讯作者：
Rosenfeld, Michael E.
影响因子：
5.8
作者：
Galluzzi, F;Stagi, S;Chiarelli, F
通讯作者：
Chiarelli, F
影响因子：
4.2
作者：
Chen, Neal X;Moe, Sharon M
通讯作者：
Moe, Sharon M
影响因子：
5.8
作者：
Browner, WS;Lui, LY;Cummings, SR
通讯作者：
Cummings, SR