Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep.
Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep.
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海拔适应：对睡眠期间周期性呼吸和化学反应的影响。
DOI：
10.1152/jappl.1987.63.1.401
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Weil,JV
中科院分区：
文献类型：
--
作者：
White,DP;Gleeson,K;Pickett,CK;Rannels,AM;Cymerman,A;Weil,JV
虽然已经仔细研究了高原习服对呼吸的影响，但低氧和高碳酸血症的呼吸反应的相关变化是有争议的，这两种反应都没有在高原睡眠期间进行过评估。因此，在海平面和到达海拔（14，110英尺）后的第1、4和7天晚上，对6名健康男性进行了研究。在清醒期间，每次测定通气量和对低氧和高碳酸血症的缓解反应。在非快速眼动睡眠和快速眼动睡眠期间，测定通气、呼吸模式和高碳酸血症呼吸反应（在环境动脉氧饱和度下测量）。本研究主要观察到四点：（1）低氧适应性反应，虽然与到达高原时的海平面值相似，但随着习服时间的延长而稳定增加，最长可达7天;（2）低氧环境下，高碳酸血症反应的斜率增加（海拔），但并没有进一步增加与适应，虽然这种反应的位置稳步向左移动（3）在高海拔地区睡眠引起的通气和高碳酸血症反应性的降低与在海平面观察到的相同，在觉醒和睡眠期间发生类似的习服;和4）在高海拔地区睡眠期间，周期性呼吸的数量变化很大，并且往往发生在对缺氧和缺氧反应更高的个体中，高碳酸血症
Although the influence of altitude acclimatization on respiration has been carefully studied, the associated changes in hypoxic and hypercapnic ventilatory responses are the subject of controversy with neither response being previously evaluated during sleep at altitude. Therefore, six healthy males were studied at sea level and on nights 1, 4, and 7 after arrival at altitude (14,110 ft). During wakefulness, ventilation and the ventilatory responses to hypoxia and hypercapnia were determined on each occasion. During both non-rapid-eye-movement and rapid-eye-movement sleep, ventilation, ventilatory pattern, and the hypercapnic ventilatory response (measured at ambient arterial O2 saturation) were determined. There were four primary observations from this study: 1) the hypoxic ventilatory response, although similar to sea level values on arrival at altitude, increased steadily with acclimatization up to 7 days; 2) the slope of the hypercapnic ventilatory response increased on initial exposure to a hypoxic environment (altitude) but did not increase further with acclimatization, although the position of this response shifted steadily to the left (lower PCO2 values); 3) the sleep-induced decrements in both ventilation and hypercapnic responsiveness at altitude were equivalent to those observed at sea level with similar acclimatization occurring during wakefulness and sleep; and 4) the quantity of periodic breathing during sleep at altitude was highly variable and tended to occur more frequently in individuals with higher ventilatory responses to both hypoxia and hypercapnia.
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影响因子：
4.7
作者：
WilleJr,JJ;Pittelkow,MR;Scott,RE
通讯作者：
Scott,RE
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DOI：
--
发表时间：
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期刊：
影响因子：
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作者：
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R. Ham
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DOI：
10.1111/1523-1747.ep12285684
发表时间：
1986
期刊：
The Journal of investigative dermatology
影响因子：
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作者：
Pittelkow,MR;WilleJr,JJ;Scott,RE
通讯作者：
Scott,RE
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DOI：
10.1111/1523-1747.ep12456848
发表时间：
1986
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Schallreuter,KU;Pittelkow,MR;Wood,JM
通讯作者：
Wood,JM
影响因子：
64.5
作者：
GREEN, H
通讯作者：
GREEN, H