Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells.
Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells.
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DOI：
10.1016/j.virol.2009.11.038
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发表时间：
2010-03-15
期刊：
影响因子：
3.7
通讯作者：
Weinberg, Adriana
中科院分区：
文献类型：
--
作者：
Tovar-Salazar, Adriana;Patterson-Bartlett, Julie;Jesser, Renee;Weinberg, Adriana
CMV infection is characterized by high of frequencies of CD27−CD28− T cells. Here we demonstrate that CMV-specific CD4+CD27−CD28− cells are regulatory T cells (TR). CD4+CD27−CD28− cells sorted from CMV-stimulated PBMC of CMV-seropositive donors inhibited de novo CMV-specific proliferation of autologous PBMC in a dose dependent fashion. Compared with the entire CMV-stimulated CD4+ T-cell population, higher proportions of CD4+CD27−CD28− TR expressed FoxP3, TGFβ, granzyme B, perforin, GITR and PD-1, lower proportions expressed CD127 and PD1-L and similar proportions expressed CD25, CTLA4, FasL and GITRL. CMV-CD4+CD27−CD28− TR expanded in response to IL-2, but not to CMV antigenic re-stimulation. The anti-proliferative effect of CMV-CD4+CD27−CD28− TR significantly decreased after granzyme B or TGFβ inhibition. The CMV-CD4+CD27−CD28− TR of HIV-infected and uninfected donors had similar phenotypes and anti-proliferative potency, but HIV-infected individuals had higher proportions of CMV-CD4+CD27−CD28− TR. The CMV-CD4+CD27−CD28− TR may contribute to the down-regulation of CMV-specific and nonspecific immune responses of CMV-infected individuals.
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