Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis.
Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis.
复制标题
DOI：
10.1007/s10552-011-9835-3
复制
发表时间：
2011-11
影响因子：
2.3
通讯作者：
Troisi, Rebecca
中科院分区：
文献类型：
--
作者：
Faupel-Badger, Jessica M.;Wang, Yuping;Karumanchi, S. Ananth;Stanczyk, Frank;Pollak, Michael;McElrath, Thomas;Hoover, Robert N.;Troisi, Rebecca
这项研究的目的是全面分析怀孕期间的生物因素，这些因素被认为是子宫内环境的重要组成部分，也可能与以后对癌症和其他慢性疾病的易感性有关。测量足月、血压正常妊娠的母体血清和脐带血清中的类固醇性激素、IGF 和血管生成因子。 Spearman 相关性和线性回归估计了生物因素和临床特征之间的关系。母体和胎儿循环之间的分析物通常不相关。然而，母体或脐带样本中的几种分析物之间存在显着相关性。一些分析物与临床特征相关（例如，母体 IGF-1 和 IGFBP-3 与后代出生体重呈负相关，而母体瘦素和脐带睾酮与该特征呈正相关）。非裔美国人的母体雄激素高于白人，男性后代的母体 PlGF 和可溶性 fms 样酪氨酸激酶 1 (sFlt-1) 高于女性后代。分析物之间存在显着相关性，但模式有所不同，具体取决于它们是在母体循环中还是在胎儿循环中测量。然而，分析物之间相关性的数量和程度应该会影响未来研究的设计和解释。
The objective of this study was to comprehensively profile biological factors in pregnancy that have been postulated to be important components of the in utero environment and may also have relevance to later susceptibility to cancer and other chronic diseases. Steroid sex hormones, IGFs, and angiogenic factors were measured in maternal and cord serum from term, normotensive pregnancies. Spearman correlations and linear regression estimated relationships among the biological factors and clinical characteristics. The analytes were generally not correlated between maternal and fetal circulations. However, significant correlations were demonstrated among several analytes within maternal or cord samples. A few analytes were associated with clinical characteristics (e.g., maternal IGF-1and IGFBP-3 were inversely correlated with offspring birth weight, while maternal leptin and cord testosterone were positively correlated with this characteristic). Maternal androgens were higher in African-Americans than whites and maternal PlGF and soluble fms-like tyrosine kinase-1 (sFlt-1) were higher in male than female offspring. There were significant correlations among analytes but the patterns differed depending on whether they were measured in the maternal or fetal circulation. The number and magnitude of correlations among analytes, however, should affect the design and interpretation of future studies.
登录
查看更多内容
影响因子：
1.8
作者：
Romero, Roberto;Nien, Jyh Kae;Karumanchi, S. Ananth
通讯作者：
Karumanchi, S. Ananth
影响因子：
2.7
作者：
SCOTT, JZ;STANCZYK, FZ;MISHELL, DR
通讯作者：
MISHELL, DR
DOI：
10.1016/j.ejogrb.2005.07.007
发表时间：
2006-05-01
影响因子：
2.6
作者：
Salamalekis, Emanouel;Bakas, Panagiotis;Creatsas, Georgios
通讯作者：
Creatsas, Georgios
影响因子：
6.4
作者：
Caughey, Robert W.;Michels, Karin B.
通讯作者：
Michels, Karin B.
影响因子：
2.7
作者：
KATAGIRI, H;STANCZYK, FZ;GOEBELSMANN, U
通讯作者：
GOEBELSMANN, U