Tentative evidence for striatal hyperactivity in adolescent cannabis-using boys: a cross-sectional multicenter fMRI study.
Tentative evidence for striatal hyperactivity in adolescent cannabis-using boys: a cross-sectional multicenter fMRI study.
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DOI：
10.1080/02791072.2013.785837
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发表时间：
2013-04
影响因子：
2.8
通讯作者：
Ramsey NF
中科院分区：
文献类型：
--
作者：
Jager G;Block RI;Luijten M;Ramsey NF
青少年的冒险行为与成熟期奖励（“去”）和控制（“停”）相关大脑回路之间的不平衡有关。这可能会导致青少年吸毒，如大麻的使用。在这项研究中，我们评估了青少年使用大麻对奖励相关脑功能的非急性影响。我们进行了一项双中心（美国和荷兰;汇总数据）功能性磁共振成像（fMRI）研究，采用横断面设计。21名禁欲但经常使用大麻的男孩与24名不使用大麻的同龄人在奖励相关的大脑功能上进行了比较，使用了功能磁共振成像的金钱激励延迟任务。重点是奖励的预期和反应阶段以及与奖励处理密切相关的大脑区域，如纹状体。用户表现正常。区域的利益分析表明，在预期阶段的奖励在用户的纹状体活动过度。有趣的是，这种效应在非奖励性活动中最为明显。青少年大麻使用者的纹状体活动过度可能意味着过度敏感的动机脑回路。在青春期经常使用大麻可能会导致在无法获得奖励时脱离动机回路的能力下降。这可以加强对滥用药物等强化措施的寻求，即使面临负面（非奖励）后果。
Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward (“go”) and inhibitory-control (“stop”) related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.
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DOI：
10.1523/jneurosci.1506-12.2012
发表时间：
2012-07-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Stice E;Yokum S;Burger K;Epstein L;Smolen A
通讯作者：
Smolen A
影响因子：
1.7
作者：
DEFONSECA, FR;RAMOS, JA;FERNANDEZRUIZ, JJ
通讯作者：
FERNANDEZRUIZ, JJ
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW
DOI：
10.1097/00004583-200001000-00014
发表时间：
2000-01-01
影响因子：
13.3
作者：
Shaffer, D;Fisher, P;Schwab-Stone, ME
通讯作者：
Schwab-Stone, ME
影响因子：
3.6
作者：
Geier, Charles;Luna, Beatriz
通讯作者：
Luna, Beatriz