Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain.
Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain.
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prion发病机理和继发性淋巴机构（SLO）：追踪王室对大脑的SLO传播。
作者：
Mabbott NA
朊病毒疾病是影响人类以及一系列家养和自由放养动物的亚急性神经退行性疾病。这些疾病的特点是 PrPSc（一种细胞朊病毒蛋白 (PrPC) 的异常折叠亚型）在受影响的组织中积聚。朊病毒病的病理似乎几乎完全发生在中枢神经系统内。发生的广泛的神经变性最终导致宿主死亡。与其他蛋白质错误折叠疾病相比，朊病毒疾病的一个有趣特征是它们的传播性。外周暴露后，一些朊病毒疾病在淋巴组织内积聚至高水平。朊病毒在淋巴组织内的复制已被证明对于疾病有效传播到大脑非常重要。本文描述了我们对影响朊病毒从外周暴露部位（例如肠腔）传播到大脑的细胞机制的理解的最新进展。对这些事件的透彻了解将有助于确定治疗干预的重要目标，或者揭示影响外周获得性朊病毒疾病易感性的其他过程。
Prion diseases are subacute neurodegenerative diseases that affect humans and a range of domestic and free-ranging animal species. These diseases are characterized by the accumulation of PrPSc, an abnormally folded isoform of the cellular prion protein (PrPC), in affected tissues. The pathology during prion disease appears to occur almost exclusively within the central nervous system. The extensive neurodegeneration which occurs ultimately leads to the death of the host. An intriguing feature of the prion diseases, when compared with other protein-misfolding diseases, is their transmissibility. Following peripheral exposure, some prion diseases accumulate to high levels within lymphoid tissues. The replication of prions within lymphoid tissue has been shown to be important for the efficient spread of disease to the brain. This article describes recent progress in our understanding of the cellular mechanisms that influence the propagation of prions from peripheral sites of exposure (such as the lumen of the intestine) to the brain. A thorough understanding of these events will lead to the identification of important targets for therapeutic intervention, or alternatively, reveal additional processes that influence disease susceptibility to peripherally-acquired prion diseases.
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影响因子：
2.8
作者：
Bradford, Barry M.;Sester, David P.;Mabbott, Neil A.
通讯作者：
Mabbott, Neil A.
影响因子：
4.2
作者：
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通讯作者：
Gabizon, Ruth
影响因子：
82.9
作者：
Brown, KL;Stewart, K;Bruce, ME
通讯作者：
Bruce, ME
影响因子：
82.9
作者：
Castilla, J;Saá, P;Soto, C
通讯作者：
Soto, C
影响因子：
4.6
作者：
CARP, RI;CALLAHAN, SM
通讯作者：
CALLAHAN, SM