A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung.
A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung.
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DOI：
10.1002/ijc.24983
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发表时间：
2010-06-01
影响因子：
6.4
通讯作者：
Demant, Peter
中科院分区：
文献类型：
--
作者：
Quan, Lei;Hutson, Alan;Demant, Peter
肺肿瘤形成的区域特异性很少在小鼠或人中研究。利用肺癌易感基因Sluc 20的半同源品系杂交，我们分析了Sluc 20和其他五个基因座对小鼠肺肿瘤区域性的遗传影响。我们已经将Sluc 20定位到8号染色体的27.92MB近端区域，发现它仅控制那些围绕或直接邻近支气管或细支气管的肿瘤（支气管周围肿瘤）的数量和负荷。这些肿瘤位于支气管基底膜之外，并且往往比肺中其他位置的肿瘤更大。与其他部位的肺泡系肿瘤相似，支气管周围肿瘤用SP-C而不是CC-10抗体染色。Sluc 20等位基因的影响是加性的，因为杂合子中支气管周围肿瘤的数量是中等的。这些发现揭示了小鼠肺中的肿瘤区域性，这代表了肺肿瘤异质性的新水平，是在特定的遗传控制下。控制肺癌区域性的基因的鉴定将为肺癌生物学提供新的见解，并可能提高人类肺癌个体化预后和治疗的可能性。
Regional specificity of lung tumor formation has rarely been studied in mouse or human. By using crosses of strains semi-congenic for lung cancer susceptibility locus Sluc20, we have analyzed the genetic influences of Sluc20 and five other loci on tumor regionality in the mouse lung. We have mapped Sluc20 to a 27.92MB proximal region of chromosome 8 and found that it controls the number and load of only those tumors that surround or are directly adjacent to the bronchi or bronchioli (peribronchial tumors). These tumors lie outside the bronchial basement membrane and tend to reach a larger size than the tumors at other locations in the lung. Similarly to tumors of alveolar lineage at other locations, peribronchial tumors stain with SP-C but not CC-10 antibody. The effects of Sluc20 alleles are additive as the number of peribronchial tumors in heterozygotes is intermediate. These findings reveal that tumor regionality in the mouse lung, which represents a novel level of lung tumor heterogeneity, is under specific genetic control. The identification of genes controlling lung tumor regionality will provide novel insights into biology of lung tumors and potentially improve the possibilities of individualized prognosis and treatment in human lung cancer.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
3.2
作者：
DEMANT, P;HART, AAM
通讯作者：
HART, AAM
DOI：
10.1093/jnci/93.19.1484
发表时间：
2001-10-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Tripodis, N;Hart, AAM;Demant, P
通讯作者：
Demant, P
影响因子：
64.5
作者：
Kim, CFB;Jackson, EL;Jacks, T
通讯作者：
Jacks, T
影响因子：
6
作者：
Mason, RJ;Kalina, M;Shannon, JM
通讯作者：
Shannon, JM