Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors.
Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors.
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DOI：
10.1371/journal.pone.0201097
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Muir KR
中科院分区：
文献类型：
--
作者：
Al-Ajmi K;Lophatananon A;Ollier W;Muir KR
据报道，人体测量和生殖因素是乳腺癌 (BC) 的既定危险因素。本研究在大型纵向队列中探讨了人体测量和生殖因素对英国女性罹患 BC 的影响。对英国生物银行对 273,467 名英国女性进行的前瞻性研究的数据进行了分析。每个因素的相对风险 (RR) 和 95% 置信区间 (CI) 根据年龄、BC 家族史和剥夺评分进行调整。分析按绝经状态进行分层。在 9 年的随访中，BC 病例总数为 14,231 例，其中发生病例 3,378 例 (23.7%)，发病率为每 1000 人年 2.09 例。在绝经前，年龄、身高的增加、低BMI、低腰臀比、BC一级家族史、初潮年龄早、未生育、首次活产年龄晚、生育间隔指数高和避孕时间长均与BC风险增加显着相关。在绝经后，年龄增长、身高较高、BMI较高、一级BC家族史、未生育、首次活产年龄较晚以及生育间隔指数较高均与BC风险增加显着相关。人口归因分数 (PAF) 表明，早期首次活产、较低的生育间隔指数和增加儿童数量可有助于将 BC 风险降低高达 50%。这项研究利用英国生物银行的研究来确认人体测量和生殖因素与乳腺癌发生风险之间的关联。每个风险因素造成的风险归因分数的结果表明，通过控制体重、重新评估个人的分娩时间和避孕选择以及考虑对有一级亲属家族史的女性进行早期筛查，可以降低 BC 的终生风险。
Anthropometric and reproductive factors have been reported as being established risk factors for breast cancer (BC). This study explores the contribution of anthropometric and reproductive factors in UK females developing BC in a large longitudinal cohort. Data from the UK Biobank prospective study of 273,467 UK females were analyzed. Relative risks (RRs) and 95% confidence intervals (CIs) for each factor were adjusted for age, family history of BC and deprivation score. The analyses were stratified by the menopausal status. Over the 9 years of follow up the total number of BC cases were 14,231 with 3,378 (23.7%) incident cases with an incidence rate of 2.09 per 1000 person-years. In pre-menopausal, increase in age, height, having low BMI, low waist to hip ratio, first degree family history of BC, early menarche age, nulliparous, late age at first live birth, high reproductive interval index, and long contraceptive use duration were all significantly associated with an increased BC risk. In post-menopausal, getting older, being taller, having high BMI, first degree BC family history, nulliparous, late age at first live birth, and high reproductive interval index were all significantly associated with an increased risk of BC. The population attributable fraction (PAF) suggested that an early first live birth, lower reproductive interval index and increased number of children can contribute to BC risk reduction up to 50%. This study utilizes the UK Biobank study to confirm associations between anthropometric and reproductive factors and the risk of breast cancer development. Result of attributable fraction of risk contributed by each risk factor suggested that lifetime risk of BC can be reduced by controlling weight, reassessing individual approaches to the timing of childbirth and options for contraception and considering early screening for women with family history in the first degree relative.
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影响因子：
51.1
作者：
Green, Jane;Cairns, Benjamin J.;Casabonne, Delphine;Wright, F. Lucy;Reeves, Gillian;Beral, Valerie
通讯作者：
Beral, Valerie
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
3.9
作者：
Folkerd, Elizabeth;Dowsett, Mitch
通讯作者：
Dowsett, Mitch
影响因子：
3.7
作者：
Cheraghi Z;Poorolajal J;Hashem T;Esmailnasab N;Doosti Irani A
通讯作者：
Doosti Irani A
DOI：
10.1093/jnci/djq527
发表时间：
2011-02-16
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Beral V;Reeves G;Bull D;Green J;Million Women Study Collaborators
通讯作者：
Million Women Study Collaborators