Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
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DOI：
10.1371/journal.pone.0051446
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Doosti Irani A
中科院分区：
文献类型：
--
作者：
Cheraghi Z;Poorolajal J;Hashem T;Esmailnasab N;Doosti Irani A
关于体重指数（BMI）与乳腺癌之间的关系尚未达成普遍共识。这项荟萃分析旨在评估超重和肥胖对绝经前和绝经后乳腺癌风险的总体影响。截至 2012 年 4 月，所有主要电子数据库均已被检索，包括 Web of Knowledge、Medline、Scopus 和 ScienceDirect。此外，还检索了参考文献列表和相关科学会议数据库。所有调查 BMI 与乳腺癌之间关联的前瞻性队列和病例对照研究均被检索，无论发表日期和语言如何。女性接受评估时不考虑年龄、种族和婚姻状况。感兴趣的暴露是BMI。感兴趣的主要结果是病理证实的各种乳腺癌。使用 STROBE 检查表评估研究质量。研究选择和数据提取由两位作者分别进行。选择的效果衡量指标是队列研究中的风险比（RRi）和比率（RRa）以及病例对照研究中的比值比（OR）。在 9163 项检索到的研究中，有 50 项研究纳入荟萃分析，其中包括 15 项队列研究（涉及 2,104,203 名受试者和 3,414,806 人年）和 35 项病例对照研究（涉及 71,216 名受试者）。绝经前BMI与乳腺癌风险之间存在负相关但不显着的相关性：OR = 0.93 (95% CI 0.86, 1.02)； RRi = 0.97（95% CI 0.82，1.16）； RRa = 0.99 (95% CI 0.94, 1.05)，但在绝经后期间存在直接且显着的相关性：OR = 1.15 (95% CI 1.07, 1.24)； RRi = 1.16（95% CI 1.08，1.25）； RRa = 0.98 (95% CI 0.88, 1.09)。这项荟萃分析的结果表明，体重指数对绝经前乳腺癌的发病率没有显着影响。另一方面，超重和肥胖对乳腺癌的影响可能很小，尽管很显着，但确实很小，而且在临床上并不那么重要。
There is no universal consensus on the relationship between body mass index (BMI) and breast cancer. This meta-analysis was conducted to estimate the overall effect of overweight and obesity on breast cancer risk during pre- and post-menopausal period. All major electronic databases were searched until April 2012 including Web of Knowledge, Medline, Scopus, and ScienceDirect. Furthermore, the reference lists and related scientific conference databases were searched. All prospective cohort and case-control studies investigating the association between BMI and breast cancer were retrieved irrespective of publication date and language. Women were assessed irrespective of age, race and marital status. The exposure of interest was BMI. The primary outcome of interest was all kinds of breast cancers confirmed pathologically. Study quality was assessed using the checklist of STROBE. Study selection and data extraction were performed by two authors separately. The effect measure of choice was risk ratio (RRi) and rate ratio (RRa) for cohort studies and odds ratio (OR) in case-control studies. Of 9163 retrieved studies, 50 studies were included in meta-analysis including 15 cohort studies involving 2,104,203 subjects and 3,414,806 person-years and 35 case-control studies involving 71,216 subjects. There was an inverse but non-significant correlation between BMI and breast cancer risk during premenopausal period: OR = 0.93 (95% CI 0.86, 1.02); RRi = 0.97 (95% CI 0.82, 1.16); and RRa = 0.99 (95% CI 0.94, 1.05), but a direct and significant correlation during postmenopausal period: OR = 1.15 (95% CI 1.07, 1.24); RRi = 1.16 (95% CI 1.08, 1.25); and RRa = 0.98 (95% CI 0.88, 1.09). The results of this meta-analysis showed that body mass index has no significant effect on the incidence of breast cancer during premenopausal period. On the other hand, overweight and obesity may have a minimal effect on breast cancer, although significant, but really small and not clinically so important.
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影响因子：
6.4
作者：
Hirose, K;Takezaki, T;Tajima, K
通讯作者：
Tajima, K
城市化尼日利亚妇女的腰围比和乳腺癌风险。
影响因子：
7.4
作者：
Adebamowo, CA;Ogundiran, TO;Adenipekun, AA;Oyesegun, RA;Campbell, OB;Akang, EE;Rotimi, CN;Olopade, OI
通讯作者：
Olopade, OI
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG
影响因子：
3.8
作者：
Kim, Yeonju;Park, Sue K.;Yoo, Keun-Young
通讯作者：
Yoo, Keun-Young