Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure
Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure
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白细胞介素 11 水平升高与慢性心力衰竭患者的心脏事件相关
DOI：
10.1155/2019/1575410
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发表时间：
2019-01
影响因子：
4.6
通讯作者：
Wan Jun
中科院分区：
文献类型：
--
作者：
Ye Jing;Wang Zhen;Ye Di;Wang Yuan;Wang Menglong;Ji Qingwei;Huang Ying;Liu Ling;Shi Ying;Shi Lei;Zeng Tao;Xu Yao;Liu Jianfang;Jiang Huimin;Lin Yingzhong;Wan Jun
背景白细胞介素-11（IL-11）是一种重要的炎症细胞因子，参与心血管疾病的发生发展。然而，还没有关于IL-11在心力衰竭（HF）中的作用的研究。本研究旨在探讨IL-11水平是否与心力衰竭患者的心脏预后相关。方法测定240例慢性心力衰竭（CHF）患者和80例无明显心脏病体征的健康对照者血浆IL-11浓度。此外，我们前瞻性随访这些CHF患者至心脏事件终点。结果与对照组相比，CHF患者血浆IL-11浓度明显升高，且在纽约心功能II级、III级和IV级组逐渐升高。受试者工作特征（ROC）曲线显示，IL-11对心力衰竭的预测作用不如N-末端B型利钠肽（BNP），但IL-11对心力衰竭的预测有一定价值。此外，CHF患者根据血浆IL-11浓度类别分为3组（低，T1;中，T2;和高，T3）。多因素考克斯风险分析显示，调整混杂因素后，高血浆IL-11浓度与心脏事件的发生独立相关。此外，CHF患者根据中位血浆IL-11浓度分为两组。Kaplan-Meier分析显示，与低IL-11浓度的患者相比，高IL-11浓度的患者发生心脏事件的风险更高。结论血浆IL-11水平升高明显增加心脏事件的发生率，提示预后不良; IL-11对CHF的诊断价值虽不如BNP，但对CHF心脏事件的预测有一定价值。
Background Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associated with the cardiac prognosis in patients with HF. Methods The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. In addition, we prospectively followed these CHF patients to endpoints of cardiac events. Results Compared with the control group, the plasma IL-11 concentrations were significantly increased in the CHF patients and gradually increased in the New York Heart Association (NYHA) functional class II group, the NYHA functional class III group, and the NYHA functional class IV group. The receiver operating characteristic (ROC) curve revealed that the predictive role of IL-11 in HF is not as good as N-terminal B-type natriuretic peptide (BNP), although IL-11 has a certain value in predicting cardiac events. In addition, the CHF patients were divided into 3 groups according to the plasma IL-11 concentration category (low, T1; middle, T2; and high, T3). The multivariate Cox hazard analysis showed that the high plasma IL-11 concentrations were independently associated with the presence of cardiac events after adjustment for confounding factors. Furthermore, the CHF patients were divided into two groups based on the median plasma IL-11 concentrations. The Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations had a higher risk of cardiac events compared with those with low IL-11 concentrations. Conclusions Higher plasma IL-11 levels significantly increase the presence of cardiac events and suggest a poor outcome; although the diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value in predicting cardiac events in CHF.
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影响因子：
18.2
作者：
Meijers WC;van der Velde AR;Muller Kobold AC;Dijck-Brouwer J;Wu AH;Jaffe A;de Boer RA
通讯作者：
de Boer RA
急性胸主动脉夹层患者胸主动脉和血浆中白细胞介素 11 水平升高
影响因子：
5
作者：
Xu Yao;Ye Jing;Wang Menglong;Wang Yuan;Ji Qingwei;Huang Ying;Zeng Tao;Wang Zhen;Ye Di;Jiang Huimin;Liu Jianfang;Lin Yingzhong;Wan Jun
通讯作者：
Wan Jun
影响因子：
10.8
作者：
Panahi M;Papanikolaou A;Torabi A;Zhang JG;Khan H;Vazir A;Hasham MG;Cleland JGF;Rosenthal NA;Harding SE;Sattler S
通讯作者：
Sattler S
血清 CD121a（白细胞介素 1 受体，I 型）：一种潜在的新型冠心病炎症标志物。
影响因子：
3.7
作者：
Liu Z;Zhang M;Wu J;Zhou P;Liu Y;Wu Y;Yang Y;Lu X
通讯作者：
Lu X
DOI：
10.1007/978-3-030-19704-9_8
发表时间：
2019-11
期刊：
The Perioperative Medicine Consult Handbook
影响因子：
--
作者：
M. Lenaeus;Kelly M. Nakamura
通讯作者：
M. Lenaeus;Kelly M. Nakamura