Idiopathic constipation: too few stools and too little knowledge.
Idiopathic constipation: too few stools and too little knowledge.
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特发性便秘：大便过少，知识太少。
DOI：
10.1016/s0165-6147(98)01278-4
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发表时间：
1999
影响因子：
13.8
通讯作者：
Sushil K Sarna
中科院分区：
文献类型：
--
作者：
M. Briejer;Jan A.J Schuurkes;Sushil K Sarna
目前的认识是（2）多酚衍生物，如酚酞、比沙可啶、匹可硫酸钠;和（3）杂项化合物，如蓖麻油、甘油和多库酯钠或钙盐。三尖杉定的合成和释放似乎构成了主要的潜在作用机制14。一些刺激性泻药（antranoids）的安全性仍然存在争议15，16。另一组泻药是渗透性泻药（甘露醇、山梨醇、乳糖醇、乳果糖、镁盐、磷酸盐、柠檬酸钠）。它们增加粪便中的液体含量，并通过润滑和软化粪便来促进粪便的排出。手术（次全或全结肠切除术）仅适用于慢传输型便秘患者，这些患者对泻药治疗有抵抗力。然而，诸如腹痛的投诉通常不会通过手术缓解，有时甚至会变得更糟。有些病人在手术后仍然便秘。因此，手术似乎不是治疗慢传输型便秘的完全解决方案17。
Current AWARENESS (2) polyphenol derivatives, such as phenolphtalein, bisacodyl, sodium picosulphate; and (3) miscellaneous compounds, such as castor oil, glycerol and docusate sodium or calcium salt. Synthesis and release of prostaglandins seem to constitute the main underlying mechanism of action14. The safety of some of the stimulant laxatives (antranoids) is still controversial15, 16. Another group of laxatives are the osmotic laxatives (mannitol, sorbitol, lactitol, lactulose, magnesium salts, phosphates, sodium citrate). They increase the fluid content of the stool and facilitate expulsion of the bolus by lubricating and softening it. Surgery (subtotal or total colectomy) is indicated only in patients with slow transit constipation, who are resistant to laxative treatment. However, the complaints, such as abdominal pain, are often not eased by surgery and sometimes they even become worse. Some patients remain constipated after their surgery. Therefore, surgery does not seem to be a complete solution for the treatment of slow transit constipation17.
影响因子：
29.4
作者：
Sanders, KM
通讯作者：
Sanders, KM
影响因子：
29.4
作者：
KAUFMAN, PN;KREVSKY, B;FISHER, RS
通讯作者：
FISHER, RS