Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the first carpometacarpal (1CMC) joint: a feasibility study.
Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the first carpometacarpal (1CMC) joint: a feasibility study.
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第一腕掌 (1CMC) 关节软骨延迟钆增强 MRI (dGEMRIC)：可行性研究。
DOI：
10.1016/j.joca.2007.11.002
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发表时间：
2008
影响因子：
7
通讯作者：
McKenzie,C
中科院分区：
文献类型：
--
作者：
Williams,A;Shetty,SK;Burstein,D;Day,CS;McKenzie,C
第一腕掌（1CMC）关节位于拇指根部，是老年人1e4中症状性和影像学骨关节炎（OA）的常见部位。1CMC关节中的OA可能特别使人衰弱，因为它与钳子抓握力的降低相关，并限制了诸如书写和处理小物体4的活动。目前，1CMC OA的诊断和分期是基于体征和症状以及反应性骨变化的放射学证据5。目前，由于缺乏对早期关节内退行性变化敏感的标记物，特别是那些影像学上隐匿的标记物，从而限制了对1CMC关节OA病因和进展的更深入了解，这些标记物可用于定量评估疾病状态和治疗疗效。dGEMRIC（软骨的延迟钆增强磁共振成像[MRI]）技术先前已在膝关节和髋关节中作为非侵入性方法用于评价软骨生化状态的一个方面，即软骨糖胺聚糖（GAG）浓度6e10的空间分布，但从未应用于手部的薄软骨。这项研究发现，1CMC关节的dGEMRIC评估在技术上是可行的，并证明了无症状和OA关节软骨之间的差异，可能提供了疾病进展的客观衡量标准，并提供了更好地了解软骨破坏之前可能发生的生化变化的方法。
The first carpometacarpal (1CMC) joint, at the base of the thumb, is a common site for symptomatic and radiographic osteoarthritis (OA) among the elderly 1e4. OA in the 1CMC joint can be particularly debilitating because it is associated with a decrease in pincer grip strength and limits activities such as writing and handling small objects 4. Currently, the diagnosis and staging of 1CMC OA are based on physical signs and symptoms and radiographic evidence of reactive bone changes 5. A deeper appreciation of OA etiology and progression in the 1CMC joint is currently limited by a lack of markers sensitive to early intraarticular degenerative changes, particularly those that are radiographically occult, that can be used to quantitatively assess disease status and therapeutic efficacy. The dGEMRIC (delayed gadolinium enhanced magnetic resonance imaging [MRI] of cartilage) technique has previously been used in the knee and hip as a non-invasive method to evaluate one aspect of cartilage biochemical status, that of the spatial distribution of cartilage glycosaminoglycan (GAG) concentration 6e10, but has never been applied to the thin cartilage in the hand. This study found dGEMRIC evaluation of the 1CMC joint is technically feasible and demonstrates differences between cartilage in asymptomatic and OA joints, potentially providing an objective measure of disease progression and a means for better understanding of biochemical changes which might precede cartilage destruction.
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影响因子：
1.1
作者：
Eaton Rg;Glickel Sz
通讯作者：
Glickel Sz
影响因子：
3.3
作者：
Tiderius, Carl J.;Jessel, Rebecca;Burstein, Deborah
通讯作者：
Burstein, Deborah
拇指基底关节关节炎。
影响因子：
1.9
作者：
R. Burton;V. Pellegrini
通讯作者：
V. Pellegrini
影响因子：
19.7
作者：
Lazovic-Stojkovic, J;Mosher, TJ;Smith, MB
通讯作者：
Smith, MB
影响因子：
3.3
作者：
Tiderius, CJ;Olsson, LE;Dahlberg, L
通讯作者：
Dahlberg, L