Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen.
Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen.
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移动元件和病毒整合促使人们考虑将细菌 DNA 整合作为一种新型致癌物。
DOI：
10.1016/j.canlet.2014.05.021
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发表时间：
2014
期刊：
影响因子：
9.7
通讯作者：
DunningHotopp,JulieC
中科院分区：
文献类型：
--
作者：
Robinson,KellyM;DunningHotopp,JulieC
插入突变在癌症基因组中已被反复证实，并在肿瘤发生中发挥作用。移动的遗传元件可以通过随机插入癌症相关基因或通过诱导易位来诱导癌症发展。L1通常与上皮细胞来源的癌症有关，而L1元件与白血病以及上皮细胞癌症有关。同样，病毒感染主要通过整合到人类基因组中并使癌症相关基因突变或失调而在癌症发展中起重要作用。人乳头状瘤病毒是病毒整合导致癌症发生的最著名的例子。然而，B型肝炎病毒、爱泼斯坦-巴尔病毒和默克尔细胞多瘤病毒也整合到人类基因组中并破坏癌症相关基因。到目前为止，微生物在癌症中的作用主要归因于慢性炎症或毒素诱导的突变，如幽门螺杆菌和肠促炎脆弱类杆菌。我们假设，像移动的元件和病毒DNA一样，细菌和寄生虫DNA也可能整合到人类体细胞基因组中并致癌。直到最近，人们还认为细菌DNA不能整合到人类基因组中，但新的证据表明，细菌插入突变可能发生在癌细胞中。虽然这项工作没有显示细菌插入和癌症之间的因果关系，但它促使在这一领域进行更多的研究。有前途的新测序技术可能会降低人为嵌合序列的风险，从而减少在体细胞人类基因组中识别新插入的一些挑战。
Insertional mutagenesis has been repeatedly demonstrated in cancer genomes and has a role in oncogenesis. Mobile genetic elements can induce cancer development by random insertion into cancer related genes or by inducing translocations. L1s are typically implicated in cancers of an epithelial cell origin, whileAluelements have been implicated in leukemia as well as epithelial cell cancers. Likewise, viral infections have a significant role in cancer development predominantly through integration into the human genome and mutating or deregulating cancer related genes. Human papilloma virus is the best-known example of viral integrations contributing to carcinogenesis. However, hepatitis B virus, Epstein-Barr virus, and Merkel cell polyomavirus also integrate into the human genome and disrupt cancer related genes. Thus far, the role of microbes in cancer has primarily been attributed to mutations induced through chronic inflammation or toxins, as is the case withHelicobacter pyloriand enterotoxigenicBacteroides fragilis. We hypothesize that like mobile elements and viral DNA, bacterial and parasitic DNA may also integrate into the human somatic genome and be oncogenic. Until recently it was believed that bacterial DNA could not integrate into the human genome, but new evidence demonstrates that bacterial insertional mutagenesis may occur in cancer cells. Although this work does not show causation between bacterial insertions and cancer, it prompts more research in this area. Promising new sequencing technologies may reduce the risk of artifactual chimeric sequences, thus diminishing some of the challenges of identifying novel insertions in the somatic human genome.
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影响因子：
14.5
作者：
Konkel MK;Batzer MA
通讯作者：
Batzer MA
影响因子：
14.5
作者：
Abend JR;Jiang M;Imperiale MJ
通讯作者：
Imperiale MJ
影响因子：
3.9
作者：
Saigo, Kenichi;Yoshida, Kenichi;Inoue, Ituro
通讯作者：
Inoue, Ituro
影响因子：
4
作者：
Hancks, Dustin C.;Kazazian, Haig H., Jr.
通讯作者：
Kazazian, Haig H., Jr.
DOI：
10.1073/pnas.0831042100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Brouha, B;Schustak, J;Kazazian, HH
通讯作者：
Kazazian, HH