The human microbiome: at the interface of health and disease.

The human microbiome: at the interface of health and disease.
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DOI:
10.1038/nrg3182
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发表时间:
2012-03-13
期刊:
Nature reviews. Genetics
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其他
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在过去的十年中,随着用于询问复杂微生物群落的新技术的出现,对微生物组在人类健康中的作用的兴趣迅速增长。微生物组的大规模动态可以通过种群生态学研究中使用的许多工具和观察来描述。破译宏基因组及其聚集的遗传信息也可用于了解微生物群落的功能特性。微生物组和宏基因组可能在健康和疾病中发挥重要作用;它们的探索是人类遗传学的前沿。
Interest in the role of the microbiome in human health has burgeoned over the past decade with the advent of new technologies for interrogating complex microbial communities. The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology. Deciphering the metagenome and its aggregate genetic information also can be used to understand the functional properties of the microbial community. Both the microbiome and metagenome probably have important functions in health and disease; their exploration is a frontier in human genetics.
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