Identification of Electroencephalogram Signals in Alzheimer's Disease by Multifractal and Multiscale Entropy Analysis.
Identification of Electroencephalogram Signals in Alzheimer's Disease by Multifractal and Multiscale Entropy Analysis.
复制标题
DOI：
10.3389/fnins.2021.667614
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Ando M;Nobukawa S;Kikuchi M;Takahashi T
阿尔茨海默病(AD)是痴呆症最常见的形式，是一种主要在老年发展的进行性神经退行性疾病。近年来，有报道称，AD的早期诊断和早期干预显著延缓了疾病的进展。因此，强调早期诊断和干预。作为阿尔茨海默病患者的诊断指标，评估脑电信号对阿尔茨海默病患者时间尺度依赖性的复杂性是有效的。已经分别进行了多尺度熵分析和多重分形分析，它们作为诊断指标的有效性已经得到证实，但这些分析之间可能提高诊断准确率的互补关系尚未得到研究。我们推测，结合多尺度熵和分形分析可能会增加另一个维度，以了解AD患者脑电动力学的变化。在这项研究中，我们对AD患者和健康受试者的脑电进行了多尺度熵和多重分形分析。我们发现，使用这两种技术都可以提高分类精度。这些发现表明，多尺度熵分析和多重分形分析的使用可能会导致AD诊断工具的发展。
Alzheimer's disease (AD) is the most common form of dementia and is a progressive neurodegenerative disease that primarily develops in old age. In recent years, it has been reported that early diagnosis of AD and early intervention significantly delays disease progression. Hence, early diagnosis and intervention are emphasized. As a diagnostic index for AD patients, evaluating the complexity of the dependence of the electroencephalography (EEG) signal on the temporal scale of Alzheimer's disease (AD) patients is effective. Multiscale entropy analysis and multifractal analysis have been performed individually, and their usefulness as diagnostic indicators has been confirmed, but the complemental relationship between these analyses, which may enhance diagnostic accuracy, has not been investigated. We hypothesize that combining multiscale entropy and fractal analyses may add another dimension to understanding the alteration of EEG dynamics in AD. In this study, we performed both multiscale entropy and multifractal analyses on EEGs from AD patients and healthy subjects. We found that the classification accuracy was improved using both techniques. These findings suggest that the use of multiscale entropy analysis and multifractal analysis may lead to the development of AD diagnostic tools.
登录
查看更多内容
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
15.9
作者：
Ewers M;Sperling RA;Klunk WE;Weiner MW;Hampel H
通讯作者：
Hampel H
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
2.6
作者：
Dickerson, Bradford C.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.